Andreas Margraf
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Explore the profile of Andreas Margraf including associated specialties, affiliations and a list of published articles.
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34
Citations
757
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Recent Articles
1.
Hellenthal K, Thomas K, Ludwig N, Cappenberg A, Schemmelmann L, Tekath T, et al.
J Leukoc Biol
. 2024 Nov;
PMID: 39504570
During sterile inflammation, tissue damage induces excessive activation and infiltration of neutrophils into tissues, where they critically contribute to organ dysfunction. Tight regulation of neutrophil migration and their effector functions...
2.
Immler R, Nussbaumer K, Doerner A, El Bounkari O, Huber S, Abisch J, et al.
Proc Natl Acad Sci U S A
. 2024 Apr;
121(19):e2319057121.
PMID: 38687790
Eosinophil recruitment is a pathological hallmark of many allergic and helminthic diseases. Here, we investigated chemokine receptor CCR3-induced eosinophil recruitment in sialyltransferase mice. We found a marked decrease in eosinophil...
3.
Liu C, Gorlich D, Lowell C, Italiano J, Rossaint J, Bender M, et al.
Clin Chem Lab Med
. 2023 Dec;
62(5):999-1010.
PMID: 38037809
Objectives: Sepsis is a life-threatening condition implicating an inadequate activation of the immune system. Platelets act as modulators and contributors to immune processes. Indeed, altered platelet turnover, thrombotic events, and...
4.
Ludwig N, Thorner-van Almsick J, Mersmann S, Bardel B, Niemann S, Chasan A, et al.
Front Immunol
. 2023 Oct;
14:1259004.
PMID: 37849760
is a common cause of hospital-acquired pneumonia associated with high mortality. Adequate clinical treatment is impeded by increasing occurrence of antibiotic resistances. Understanding the underlying mechanisms of its virulence during...
5.
Thomas K, Zondler L, Ludwig N, Kardell M, Luneburg C, Henke K, et al.
JCI Insight
. 2022 Sep;
7(21).
PMID: 36107633
Acute kidney injury (AKI) represents a common complication in critically ill patients that is associated with increased morbidity and mortality. In a murine AKI model induced by ischemia/reperfusion injury (IRI),...
6.
Dhawan U, Margraf A, Lech M, Subramanian M
J Cell Mol Med
. 2022 Sep;
26(20):5267-5276.
PMID: 36098213
Hypercholesterolemia exacerbates autoimmune response and accelerates the progression of several autoimmune disorders, but the mechanistic basis is not well understood. We recently demonstrated that hypercholesterolemia is associated with increased serum...
7.
Brabenec L, Muller M, Hellenthal K, Karsten O, Pryvalov H, Otto M, et al.
Am J Respir Crit Care Med
. 2022 Jun;
206(4):488-500.
PMID: 35699655
Capillary leakage frequently occurs during sepsis and after major surgery and is associated with microvascular dysfunction and adverse outcome. Procalcitonin is a well-established biomarker in inflammation without known impact on...
8.
Margraf A, Perretti M
Cells
. 2022 Jun;
11(11).
PMID: 35681519
Inflammation is a life-saving immune reaction occurring in response to invading pathogens. Nonetheless, inflammation can also occur in an uncontrolled, unrestricted manner, leading to chronic disease and organ damage. Mechanisms...
9.
Margraf A, Liu C, Kullmar M, Meersch M, Rossaint J, Zarbock A
Cells
. 2022 Jun;
11(11).
PMID: 35681510
Acute kidney injury (AKI) is a frequent complication in critically ill patients. Supportive treatment of AKI patients is based on renal-replacement therapy, including continuous veno-venous hemofiltration (CVVH). To limit clotting...
10.
Conrad C, Yildiz D, Cleary S, Margraf A, Cook L, Schlomann U, et al.
JCI Insight
. 2022 Feb;
7(3).
PMID: 35132956
Acute respiratory distress syndrome (ARDS) results in catastrophic lung failure and has an urgent, unmet need for improved early recognition and therapeutic development. Neutrophil influx is a hallmark of ARDS...