Jan Rossaint
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Explore the profile of Jan Rossaint including associated specialties, affiliations and a list of published articles.
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85
Citations
3544
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Recent Articles
11.
Ludwig N, Hilger A, Zarbock A, Rossaint J
Cells
. 2022 Jun;
11(12).
PMID: 35741086
Platelets are among the most abundant cells in the mammalian circulation. Classical platelet functions in hemostasis and wound healing have been intensively explored and are generally accepted. During the past...
12.
Block H, Rossaint J, Zarbock A
Cells
. 2022 Jun;
11(12).
PMID: 35741047
The innate immune system is the first line of defense against invading pathogens or sterile injuries. Pattern recognition receptors (PRR) sense molecules released from inflamed or damaged cells, or foreign...
13.
Rossaint J, Meersch M, Thomas K, Mersmann S, Lehmann M, Skupski J, et al.
JCI Insight
. 2022 Jun;
7(14).
PMID: 35727636
Acute kidney injury increases morbidity and mortality, and previous studies have shown that remote ischemic preconditioning (RIPC) reduces the risk of acute kidney injury after cardiac surgery. RIPC increases urinary...
14.
Microvascular and proteomic signatures overlap in COVID-19 and bacterial sepsis: the MICROCODE study
Rovas A, Buscher K, Osiaevi I, Drost C, Sackarnd J, Tepasse P, et al.
Angiogenesis
. 2022 Jun;
25(4):503-515.
PMID: 35723762
Aims: Although coronavirus disease 2019 (COVID-19) and bacterial sepsis are distinct conditions, both are known to trigger endothelial dysfunction with corresponding microcirculatory impairment. The purpose of this study was to...
15.
Brabenec L, Muller M, Hellenthal K, Karsten O, Pryvalov H, Otto M, et al.
Am J Respir Crit Care Med
. 2022 Jun;
206(4):488-500.
PMID: 35699655
Capillary leakage frequently occurs during sepsis and after major surgery and is associated with microvascular dysfunction and adverse outcome. Procalcitonin is a well-established biomarker in inflammation without known impact on...
16.
Margraf A, Liu C, Kullmar M, Meersch M, Rossaint J, Zarbock A
Cells
. 2022 Jun;
11(11).
PMID: 35681510
Acute kidney injury (AKI) is a frequent complication in critically ill patients. Supportive treatment of AKI patients is based on renal-replacement therapy, including continuous veno-venous hemofiltration (CVVH). To limit clotting...
17.
Jauch-Speer S, Herrera-Rivero M, Ludwig N, Veras De Carvalho B, Martens L, Wolf J, et al.
Elife
. 2022 May;
11.
PMID: 35543413
The proinflammatory alarmins S100A8 and S100A9 are among the most abundant proteins in neutrophils and monocytes but are completely silenced after differentiation to macrophages. The molecular mechanisms of the extraordinarily...
18.
Li Z, Ludwig N, Thomas K, Mersmann S, Lehmann M, Vestweber D, et al.
Front Immunol
. 2022 May;
13:843782.
PMID: 35529856
Acute kidney injury (AKI) may be induced by different causes, including renal ischemia-reperfusion injury and sepsis, which represent the most common reasons for AKI in hospitalized patients. AKI is defined...
19.
Steiger S, Rossaint J, Zarbock A, Anders H
J Am Soc Nephrol
. 2021 Dec;
33(2):259-278.
PMID: 34907031
Kidney disease is a known risk factor for poor outcomes of COVID-19 and many other serious infections. Conversely, infection is the second most common cause of death in patients with...
20.
Hosseinnejad A, Ludwig N, Wienkamp A, Rimal R, Bleilevens C, Rossaint R, et al.
Biomater Sci
. 2021 Nov;
10(1):85-99.
PMID: 34812809
Neutrophil extracellular traps (NETs) are web-like chromatin structures produced and liberated by neutrophils under inflammatory conditions which also promote the activation of the coagulation cascade and thrombus formation. The formation...