Jan C Klapwijk
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Explore the profile of Jan C Klapwijk including associated specialties, affiliations and a list of published articles.
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5
Citations
7
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Recent Articles
1.
Klapwijk J, Del Rio Espinola A, Libertini S, Collin P, Fellows M, Jobling S, et al.
Hum Gene Ther
. 2024 Jul;
35(15-16):527-542.
PMID: 39049734
Regulators and industry are actively seeking improvements and alternatives to current models and approaches to evaluate potential carcinogenicity of gene therapies (GTs). A meeting of invited experts was organized by...
2.
Cadilla R, Deaton D, Do Y, Elkins P, Ennulat D, Guss J, et al.
Bioorg Med Chem
. 2020 Oct;
28(23):115791.
PMID: 33059303
GlaxoSmithKline and Astex Pharmaceuticals recently disclosed the discovery of the potent H-PGDS inhibitor GSK2894631A 1a (IC = 9.9 nM) as part of a fragment-based drug discovery collaboration with Astex Pharmaceuticals....
3.
Hailey J, Maleeff B, Thomas H, Pearse G, Klapwijk J, Cristofori P, et al.
Toxicol Pathol
. 2017 Dec;
45(8):1055-1066.
PMID: 29233079
To test the diagnostic approach described in part 1 of this article, 2 exercises were completed by pathologists from multiple companies/agencies. Pathologist's examination of whole slide image (WSI) heart sections...
4.
Hailey J, Maleeff B, Thomas H, Pearse G, Klapwijk J, Cristofori P, et al.
Toxicol Pathol
. 2017 Nov;
45(8):1043-1054.
PMID: 29173114
Spontaneous rodent progressive cardiomyopathy (PCM) in the Sprague Dawley rat may confound identification and/or interpretation of potential test article (TA)-related cardiotoxicity. Pathologists apply diagnostic term(s) and thresholds for diagnosing and...
5.
Keenan C, Hughes-Earle A, Maleeff B, Thomas H, Adler R, Cristofori P, et al.
Toxicol Pathol
. 2010 Aug;
38(6):995-8.
PMID: 20716787
No abstract available.