Heath C Thomas
Overview
Explore the profile of Heath C Thomas including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
190
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Recent Articles
1.
Steinbach T, Tokarz D, Co C, Harris S, McBride S, Shockley K, et al.
Toxicol Pathol
. 2024 Jun;
52(5):258-265.
PMID: 38907685
We previously developed a computer-assisted image analysis algorithm to detect and quantify the microscopic features of rodent progressive cardiomyopathy (PCM) in rat heart histologic sections and validated the results with...
2.
McDorman K, Bennet B, Colman K, Fikes J, Keirstead N, Lanning Retired L, et al.
Toxicol Pathol
. 2024 Jun;
52(2-3):138-148.
PMID: 38840532
In December 2021, the United States Food and Drug Administration (FDA) issued the final guidance for industry titled . The stated purpose of the FDA guidance is to provide information...
3.
Tokarz D, Steinbach T, Lokhande A, Srivastava G, Ugalmugle R, Co C, et al.
Toxicol Pathol
. 2020 Dec;
49(4):888-896.
PMID: 33287662
Rodent progressive cardiomyopathy (PCM) encompasses a constellation of microscopic findings commonly seen as a spontaneous background change in rat and mouse hearts. Primary histologic features of PCM include varying degrees...
4.
Hailey J, Maleeff B, Thomas H, Pearse G, Klapwijk J, Cristofori P, et al.
Toxicol Pathol
. 2017 Dec;
45(8):1055-1066.
PMID: 29233079
To test the diagnostic approach described in part 1 of this article, 2 exercises were completed by pathologists from multiple companies/agencies. Pathologist's examination of whole slide image (WSI) heart sections...
5.
Hailey J, Maleeff B, Thomas H, Pearse G, Klapwijk J, Cristofori P, et al.
Toxicol Pathol
. 2017 Nov;
45(8):1043-1054.
PMID: 29173114
Spontaneous rodent progressive cardiomyopathy (PCM) in the Sprague Dawley rat may confound identification and/or interpretation of potential test article (TA)-related cardiotoxicity. Pathologists apply diagnostic term(s) and thresholds for diagnosing and...
6.
Thomas R, Scicchitano M, Mirabile R, Chau N, Frazier K, Thomas H
Toxicol Appl Pharmacol
. 2012 May;
262(3):310-20.
PMID: 22627061
Regulatory miRNAs play a role in vascular biology and are involved in biochemical and molecular pathways dysregulated during vascular injury. Collection and integration of functional miRNA data into these pathways...
7.
Dalmas D, Scicchitano M, Mullins D, Hughes-Earle A, Tatsuoka K, Magid-Slav M, et al.
Toxicol Appl Pharmacol
. 2011 Oct;
257(2):284-300.
PMID: 21983523
Drug-induced vascular injury is frequently observed in rats but the relevance and translation to humans present a hurdle for drug development. Numerous structurally diverse pharmacologic agents have been shown to...
8.
Keenan C, Hughes-Earle A, Maleeff B, Thomas H, Adler R, Cristofori P, et al.
Toxicol Pathol
. 2010 Aug;
38(6):995-8.
PMID: 20716787
No abstract available.
9.
Vidal J, Drobatz L, Holliday D, Geiger L, Thomas H
Toxicol Pathol
. 2010 Feb;
38(2):297-302.
PMID: 20124493
The cynomolgus macaque is the most commonly used nonhuman primate in nonclinical toxicity testing, but the impact of the geographic source of cynomolgus macaque on differences in spontaneous pathology and...
10.
Thomas R, Pietrzak D, Scicchitano M, Thomas H, McFarland D, Frazier K
J Pharmacol Toxicol Methods
. 2009 Jul;
60(3):263-74.
PMID: 19577656
Introduction: There are currently few widely accepted noninvasive detection methods for drug-induced vascular damage. Circulating endothelial progenitor cell (EPC) enumeration in humans has recently gained attention as a potential biomarker...