Jan Abendroth
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Explore the profile of Jan Abendroth including associated specialties, affiliations and a list of published articles.
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95
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1317
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Recent Articles
11.
Milanes J, Yan V, Pham C, Muller F, Kwain S, Rees K, et al.
bioRxiv
. 2024 Jan;
PMID: 38293107
Infections with the pathogenic free-living amoebae can lead to life-threatening illnesses including catastrophic primary amebic meningoencephalitis (PAM). Efficacious treatment options for these infections are lacking and the mortality rate remains...
12.
Moorefield J, Konuk Y, Norman J, Abendroth J, Edwards T, Lorimer D, et al.
Acta Crystallogr F Struct Biol Commun
. 2023 Sep;
79(Pt 10):257-266.
PMID: 37728609
Inorganic pyrophosphate (PP) is generated as an intermediate or byproduct of many fundamental metabolic pathways, including DNA/RNA synthesis. The intracellular concentration of PP must be regulated as buildup can inhibit...
13.
DeBouver N, Bolejack M, Esan T, Krysan D, Hagen T, Abendroth J
Acta Crystallogr F Struct Biol Commun
. 2023 May;
79(Pt 6):137-143.
PMID: 37223974
The compound ethyl-adenosyl monophosphate ester (ethyl-AMP) has been shown to effectively inhibit acetyl-CoA synthetase (ACS) enzymes and to facilitate the crystallization of fungal ACS enzymes in various contexts. In this ...
14.
Ghafoori S, Petersen G, Conrady D, Calhoun B, Stigliano M, Baydo R, et al.
Sci Rep
. 2023 Apr;
13(1):6940.
PMID: 37117205
Influenza virus (IV) causes several outbreaks of the flu each year resulting in an economic burden to the healthcare system in the billions of dollars. Several influenza pandemics have occurred...
15.
Roquet-Baneres F, Alcaraz M, Hamela C, Abendroth J, Edwards T, Kremer L
Antimicrob Agents Chemother
. 2023 Mar;
67(4):e0160722.
PMID: 36920188
Mycobacterium fortuitum represents one of the most clinically relevant rapid-growing mycobacterial species. Treatments are complex due to antibiotic resistance and to severe side effects of effective drugs, prolonged time of...
16.
Lowe M, Cardenas A, Valentin J, Zhu Z, Abendroth J, Castro J, et al.
J Med Chem
. 2022 Oct;
65(20):14121-14143.
PMID: 36216349
Plasmepsin X (PMX) is an essential aspartyl protease controlling malaria parasite egress and invasion of erythrocytes, development of functional liver merozoites (prophylactic activity), and blocking transmission to mosquitoes, making it...
17.
Maker A, Bolejack M, Schecterson L, Hammerson B, Abendroth J, Edwards T, et al.
PNAS Nexus
. 2022 Sep;
1(4):pgac163.
PMID: 36157596
E-cadherin adhesion is regulated at the cell surface, a process that can be replicated by activating antibodies. We use cryo-electron microscopy (EM) and X-ray crystallography to examine functional states of...
18.
Alcaraz M, Roquet-Baneres F, Leon-Icaza S, Abendroth J, Boudehen Y, Cougoule C, et al.
ACS Infect Dis
. 2022 Sep;
8(10):2171-2186.
PMID: 36107992
There is an unmet medical need for effective treatments against pulmonary infections, to which cystic fibrosis (CF) patients are particularly vulnerable. Recent studies showed that the antitubercular drug isoniazid is...
19.
Hall A, Abendroth J, Bolejack M, Ceska T, DellAiera S, Ellis V, et al.
ACS Med Chem Lett
. 2022 Jul;
13(7):1099-1108.
PMID: 35859861
We describe the identification and characterization of a series of covalent inhibitors of the C-terminal kinase domain (CTKD) of MSK1. The initial hit was identified via a high-throughput screening and...
20.
Milanes J, Suryadi J, Monaghan N, Harding E, Morris C, Rozema S, et al.
Antimicrob Agents Chemother
. 2022 May;
66(6):e0237321.
PMID: 35604214
Infection with pathogenic free-living amoebae, including Naegleria fowleri, spp., and Balamuthia mandrillaris, can lead to life-threatening illnesses, primarily because of catastrophic central nervous system involvement. Efficacious treatment options for these...