Jan-Michael Peters
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Explore the profile of Jan-Michael Peters including associated specialties, affiliations and a list of published articles.
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140
Citations
14216
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Recent Articles
11.
Pobegalov G, Chu L, Peters J, Molodtsov M
Nat Commun
. 2023 Jul;
14(1):3946.
PMID: 37402740
Spatial organization of DNA is facilitated by cohesin protein complexes that move on DNA and extrude DNA loops. How cohesin works mechanistically as a molecular machine is poorly understood. Here,...
12.
Batty P, Langer C, Takacs Z, Tang W, Blaukopf C, Peters J, et al.
EMBO J
. 2023 Jun;
42(16):e113475.
PMID: 37357575
Genetic information is stored in linear DNA molecules, which are highly folded inside cells. DNA replication along the folded template path yields two sister chromatids that initially occupy the same...
13.
Barth R, Pradhan B, Kim E, Davidson I, van der Torre J, Peters J, et al.
Sci Rep
. 2023 May;
13(1):8100.
PMID: 37208374
DNA loop extrusion by structural-maintenance-of-chromosome (SMC) complexes has emerged as a primary organizing principle for chromosomes. The mechanism by which SMC motor proteins extrude DNA loops is still unresolved and...
14.
Hill L, Wutz G, Jaritz M, Tagoh H, Calderon L, Peters J, et al.
Nat Commun
. 2023 Apr;
14(1):2316.
PMID: 37085514
Extended loop extrusion across the immunoglobulin heavy-chain (Igh) locus facilitates V-DJ recombination following downregulation of the cohesin-release factor Wapl by Pax5, resulting in global changes in the chromosomal architecture of...
15.
Davidson I, Barth R, Zaczek M, van der Torre J, Tang W, Nagasaka K, et al.
Nature
. 2023 Apr;
616(7958):822-827.
PMID: 37076620
In eukaryotes, genomic DNA is extruded into loops by cohesin. By restraining this process, the DNA-binding protein CCCTC-binding factor (CTCF) generates topologically associating domains (TADs) that have important roles in...
16.
Banigan E, Tang W, van den Berg A, Stocsits R, Wutz G, Brandao H, et al.
Proc Natl Acad Sci U S A
. 2023 Mar;
120(11):e2210480120.
PMID: 36897969
Cohesin folds mammalian interphase chromosomes by extruding the chromatin fiber into numerous loops. "Loop extrusion" can be impeded by chromatin-bound factors, such as CTCF, which generates characteristic and functional chromatin...
17.
Pradhan B, Barth R, Kim E, Davidson I, Bauer B, van Laar T, et al.
Cell Rep
. 2022 Oct;
41(3):111491.
PMID: 36261017
Ring-shaped structural maintenance of chromosomes (SMC) complexes like condensin and cohesin extrude loops of DNA. It remains, however, unclear how they can extrude DNA loops in chromatin that is bound...
18.
Dequeker B, Scherr M, Brandao H, Gassler J, Powell S, Gaspar I, et al.
Nature
. 2022 May;
606(7912):197-203.
PMID: 35585235
Eukaryotic genomes are compacted into loops and topologically associating domains (TADs), which contribute to transcription, recombination and genomic stability. Cohesin extrudes DNA into loops that are thought to lengthen until...
19.
Panarotto M, Davidson I, Litos G, Schleiffer A, Peters J
Proc Natl Acad Sci U S A
. 2022 Apr;
119(18):e2201029119.
PMID: 35476527
Cornelia de Lange syndrome (CdLS) is a developmental multisystem disorder frequently associated with mutations in NIPBL. CdLS is thought to arise from developmental gene regulation defects, but how NIPBL mutations...
20.
Bauer B, Davidson I, Canena D, Wutz G, Tang W, Litos G, et al.
Cell
. 2021 Oct;
184(21):5448-5464.e22.
PMID: 34624221
Structural maintenance of chromosomes (SMC) complexes organize genome topology in all kingdoms of life and have been proposed to perform this function by DNA loop extrusion. How this process works...