Brenda A Schulman
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Explore the profile of Brenda A Schulman including associated specialties, affiliations and a list of published articles.
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174
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11763
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Recent Articles
1.
Muhar M, Farnung J, Cernakova M, Hofmann R, Henneberg L, Pfleiderer M, et al.
Nature
. 2025 Jan;
638(8050):519-527.
PMID: 39880951
During normal cellular homeostasis, unfolded and mislocalized proteins are recognized and removed, preventing the build-up of toxic byproducts. When protein homeostasis is perturbed during ageing, neurodegeneration or cellular stress, proteins...
2.
Kraus F, He Y, Swarup S, Overmyer K, Jiang Y, Brenner J, et al.
Sci Adv
. 2025 Jan;
11(4):eadu5787.
PMID: 39841834
Lysosomal storage diseases (LSDs) comprise ~50 monogenic disorders marked by the buildup of cellular material in lysosomes, yet systematic global molecular phenotyping of proteins and lipids is lacking. We present...
3.
Alkhalaf L, Arrowsmith C, Balskus E, Bergamini G, Bhandari R, Chang C, et al.
Nat Chem Biol
. 2024 Dec;
21(1):6-15.
PMID: 39719500
No abstract available.
4.
Scott D, Chittori S, Purser N, King M, Maiwald S, Churion K, et al.
Nat Commun
. 2024 Nov;
15(1):9899.
PMID: 39548056
Specificity of the ubiquitin-proteasome system depends on E3 ligase-substrate interactions. Many such pairings depend on E3 ligases binding to peptide-like sequences - termed N- or C-degrons - at the termini...
5.
6.
Scott D, Dharuman S, Griffith E, Chai S, Ronnebaum J, King M, et al.
Nat Commun
. 2024 Oct;
15(1):8829.
PMID: 39396041
PROTAC® (proteolysis-targeting chimera) molecules induce proximity between an E3 ligase and protein-of-interest (POI) to target the POI for ubiquitin-mediated degradation. Cooperative E3-PROTAC-POI complexes have potential to achieve neo-substrate selectivity beyond...
7.
Hennes E, Lucas B, Scholes N, Cheng X, Scott D, Bischoff M, et al.
bioRxiv
. 2024 Jul;
PMID: 39026748
Targeted protein degradation (TPD) modulates protein function beyond inhibition of enzyme activity or protein-protein interactions. Most degrader drugs function by directly mediating proximity between a neosubstrate and hijacked E3 ligase....
8.
Kagiou C, Cisneros J, Farnung J, Liwocha J, Offensperger F, Dong K, et al.
Nat Commun
. 2024 Jun;
15(1):5409.
PMID: 38926334
Targeted protein degradation (TPD) relies on small molecules to recruit proteins to E3 ligases to induce their ubiquitylation and degradation by the proteasome. Only a few of the approximately 600...
9.
Yi S, Sepic S, Schulman B, Ordureau A, An H
Mol Cell
. 2024 May;
84(11):2166-2184.e9.
PMID: 38788716
Mammalian target of rapamycin (mTOR) senses changes in nutrient status and stimulates the autophagic process to recycle amino acids. However, the impact of nutrient stress on protein degradation beyond autophagic...
10.
Gottemukkala K, Chrustowicz J, Sherpa D, Sepic S, Vu D, Karayel O, et al.
Mol Cell
. 2024 May;
84(10):1948-1963.e11.
PMID: 38759627
The yeast glucose-induced degradation-deficient (GID) E3 ubiquitin ligase forms a suite of complexes with interchangeable receptors that selectively recruit N-terminal degron motifs of metabolic enzyme substrates. The orthologous higher eukaryotic...