Jamin D Boggs
Overview
Explore the profile of Jamin D Boggs including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
128
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Recent Articles
1.
Bonaventure P, Aluisio L, Shoblock J, Boggs J, Fraser I, Lord B, et al.
PLoS One
. 2011 Jun;
6(6):e20210.
PMID: 21701689
The role of 5-HT₇ receptor has been demonstrated in various animal models of mood disorders; however its function in cognition remains largely speculative. This study evaluates the effects of SB-269970,...
2.
Santillan Jr A, McClure K, Allison B, Lord B, Boggs J, Morton K, et al.
Bioorg Med Chem Lett
. 2010 Sep;
20(21):6226-30.
PMID: 20843691
Previous research on histamine H(3) antagonists has led to the development of a pharmacophore model consisting of a central phenyl core flanked by two alkylamine groups. Recent investigation of the...
3.
Swanson D, Shah C, Lord B, Morton K, Dvorak L, Mazur C, et al.
Eur J Med Chem
. 2009 Jul;
44(11):4413-25.
PMID: 19577344
A series of small molecules consisting of a heterocyclic core flanked by two basic functionalities were synthesized and screened for in vitro affinity at the human histamine H(3) receptor (hH(3)R)....
4.
Galici R, Boggs J, Aluisio L, Fraser I, Bonaventure P, Lord B, et al.
Neuropharmacology
. 2009 Apr;
56(8):1131-7.
PMID: 19345233
Histamine 3 (H(3)) receptors are distributed throughout the brain and regulate histamine as well as the activity of other neurotransmitters including acetylcholine (ACh). Impaired ACh neurotransmission is associated with deficits...
5.
Jablonowski J, Ly K, Bogenstaetter M, Dvorak C, Boggs J, Dvorak L, et al.
Bioorg Med Chem Lett
. 2009 Jan;
19(3):903-7.
PMID: 19119007
A novel series of imidazole containing histamine H(3) receptor ligands were investigated and found to be potent functional antagonists. After improving the stability of these molecules towards liver microsomes, these...
6.
Galici R, Boggs J, Miller K, Bonaventure P, Atack J
Behav Pharmacol
. 2008 Mar;
19(2):153-9.
PMID: 18332680
5-HT7 receptors have been linked to a number of psychiatric disorders including anxiety and depression. The localization of 5-HT7 receptors in the thalamus, a key sensory processing center, and the...
7.
Ly K, Letavic M, Keith J, Miller J, Stocking E, Barbier A, et al.
Bioorg Med Chem Lett
. 2007 Dec;
18(1):39-43.
PMID: 18060777
The synthesis and biological activity of a new series of piperazine and diazepane amides is described. The new compounds are high affinity histamine H3 ligands and serotonin reuptake inhibitors.
8.
Keith J, Barbier A, Wilson S, Miller K, Boggs J, Fraser I, et al.
Bioorg Med Chem Lett
. 2007 Sep;
17(19):5325-9.
PMID: 17765543
A series of tetrahydroisoquinolines acting as dual serotonin transporter inhibitor/histamine H(3) antagonists is described. The introduction of polar aromatic spacers as part of the histamine H(3) pharmacophore was explored. A...
9.
Barbier A, Aluisio L, Lord B, Qu Y, Wilson S, Boggs J, et al.
Eur J Pharmacol
. 2007 Sep;
576(1-3):43-54.
PMID: 17765221
Wake-promoting agents such as modafinil are used in the clinic as adjuncts to antidepressant therapy in order to alleviate lethargy. The wake-promoting action of histamine H(3) receptor antagonists has been...
10.
Letavic M, Stocking E, Barbier A, Bonaventure P, Boggs J, Lord B, et al.
Bioorg Med Chem Lett
. 2007 Jul;
17(17):4799-803.
PMID: 17616397
The design, synthesis, and in vitro activity of a series of novel 5-ethynyl-2-aryloxybenzylamine-based histamine H(3) ligands that are also serotonin reuptake transporters is described.