Timothy W Lovenberg
Overview
Explore the profile of Timothy W Lovenberg including associated specialties, affiliations and a list of published articles.
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93
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2132
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Recent Articles
1.
Preville C, Bonaventure P, Koudriakova T, Lord B, Nepomuceno D, Rizzolio M, et al.
ACS Med Chem Lett
. 2020 Oct;
11(10):2002-2009.
PMID: 33062185
The orexin system consists of two neuropeptides (orexin-A and orexin-B) that exert their mode of action on two receptors (orexin-1 and orexin-2). While the role of the orexin-2 receptor is...
2.
Wu C, Huang B, Chen G, Lovenberg T, Pocalyko D, Yao X
Front Genet
. 2019 May;
10:396.
PMID: 31114610
Transcriptomics technologies such as next-generation sequencing and microarray platforms provide exciting opportunities for improving diagnosis and treatment of complex diseases. Transcriptomics studies often share similar hypotheses, but are carried out...
3.
Wang L, Lee G, Kuei C, Yao X, Harrington A, Bonaventure P, et al.
Front Neurosci
. 2019 Apr;
13:281.
PMID: 30971885
GPR139, a G-coupled receptor that is activated by the essential amino acids L-tryptophan and L-phenylalanine, is predominantly expressed in the brain and pituitary. The physiological function of GPR139 remains elusive...
4.
Fourgeaud L, Dvorak C, Faouzi M, Starkus J, Sahdeo S, Wang Q, et al.
Eur J Pharmacol
. 2019 Apr;
853:299-307.
PMID: 30965058
Transient receptor potential melastatin type 2 (TRPM2) is a cation channel activated by free intracellular ADP-ribose and reactive oxygen species. TRPM2 signaling has been linked to the pathophysiology of CNS...
5.
Savall B, Wu D, Swanson D, Seierstad M, Wu N, Vives Martinez J, et al.
ACS Med Chem Lett
. 2019 Mar;
10(3):267-272.
PMID: 30891124
This report discloses the discovery and characterization of imidazo[1,2-]pyrazines and pyrazolo[1,5-]pyrimidines as selective negative modulators of α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors (AMPARs) associated with transmembrane AMPAR regulatory protein γ-8. Imidazopyrazine was initially identified...
6.
Carruthers N, Lovenberg T, Traynelis S
ACS Med Chem Lett
. 2019 Mar;
10(3):226.
PMID: 30891117
No abstract available.
7.
Wang L, Lee G, Shih A, Kuei C, Nepomuceno D, Wennerholm M, et al.
Pharmacol Res Perspect
. 2019 Feb;
7(1):e00466.
PMID: 30774960
GPR139 is a Gq-coupled receptor activated by the essential amino acids L-tryptophan (L-Trp) and L-phenylalanine (L-Phe). We carried out mutagenesis studies of the human GPR139 receptor to identify the critical...
8.
Ravula S, Savall B, Wu N, Lord B, Coe K, Wang K, et al.
ACS Med Chem Lett
. 2018 Aug;
9(8):821-826.
PMID: 30128074
Glutamate mediates fast excitatory neurotransmission via ionotropic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. The trafficking and gating properties of AMPA receptors (AMPARs) can be amplified by transmembrane AMPAR regulatory proteins (TARPs), which...
9.
Bhattacharya A, Lord B, Grigoleit J, He Y, Fraser I, Campbell S, et al.
Neuropsychopharmacology
. 2018 Jul;
43(13):2586-2596.
PMID: 30026598
Emerging data continues to point towards a relationship between neuroinflammation and neuropsychiatric disorders. ATP-induced activation of P2X7 results in IL-1β release causing neuroinflammation and microglial activation. This study describes the...
10.
Carruthers N, Lovenberg T, Traynelis S
ACS Med Chem Lett
. 2018 May;
9(5):398-399.
PMID: 29795747
Call for papers! is now accepting manuscript submissions for a special issue entitled "Allosteric Modulation of Ionotropic Glutamate Receptors". This special issue is a cross-thematic issue with and . The...