James W Horner
Overview
Explore the profile of James W Horner including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
3103
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0
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Recent Articles
1.
Li J, Lan Z, Liao W, Horner J, Xu X, Liu J, et al.
Nature
. 2023 Jun;
619(7970):632-639.
PMID: 37344599
Sex exerts a profound impact on cancer incidence, spectrum and outcomes, yet the molecular and genetic bases of such sex differences are ill-defined and presumptively ascribed to X-chromosome genes and...
2.
Davidson S, Schmidt D, Heyman J, OBrien J, Liu A, Israelsen W, et al.
Cancer Res
. 2022 May;
82(13):2403-2416.
PMID: 35584006
Differential expression of PKM1 and PKM2 impacts prostate tumorigenesis and suggests a potential therapeutic vulnerability in prostate cancer.
3.
Shim H, Horner J, Wu C, Li J, Lan Z, Jiang S, et al.
Nat Aging
. 2022 Jan;
1(12):1162-1174.
PMID: 35036927
Amyloid-induced neurodegeneration plays a central role in Alzheimer's disease (AD) pathogenesis. Here, we show that haploinsufficiency decreases BDNF and increases amyloid-β (Aβ) precursor in murine brain. Moreover, prior to disease...
4.
Zhao D, Cai L, Lu X, Liang X, Li J, Chen P, et al.
Cancer Discov
. 2020 May;
10(9):1374-1387.
PMID: 32385075
Genetic inactivation of is common in prostate cancer and correlates with poorer prognosis. We previously identified as an essential gene in PTEN-deficient cancer cells. Here, we sought definitive genetic evidence...
5.
Lu X, Horner J, Paul E, Shang X, Troncoso P, Deng P, et al.
Nature
. 2017 May;
545(7652):116.
PMID: 28470201
No abstract available.
6.
Lu X, Horner J, Paul E, Shang X, Troncoso P, Deng P, et al.
Nature
. 2017 Mar;
543(7647):728-732.
PMID: 28321130
A significant fraction of patients with advanced prostate cancer treated with androgen deprivation therapy experience relapse with relentless progression to lethal metastatic castration-resistant prostate cancer (mCRPC). Immune checkpoint blockade using...
7.
Shingu T, Ho A, Yuan L, Zhou X, Dai C, Zheng S, et al.
Nat Genet
. 2016 Nov;
49(1):75-86.
PMID: 27841882
Stem cells, including cancer stem cells (CSCs), require niches to maintain stemness, yet it is unclear how CSCs maintain stemness in the suboptimal environment outside their niches during invasion. Postnatal...
8.
Rai K, Akdemir K, Kwong L, Fiziev P, Wu C, Keung E, et al.
Cancer Discov
. 2015 Oct;
5(12):1314-27.
PMID: 26450788
Unlabelled: Epigenetic regulators have emerged as critical factors governing the biology of cancer. Here, in the context of melanoma, we show that RNF2 is prognostic, exhibiting progression-correlated expression in human...
9.
Colla S, Ong D, Ogoti Y, Marchesini M, Mistry N, Clise-Dwyer K, et al.
Cancer Cell
. 2015 May;
27(5):644-57.
PMID: 25965571
Myelodysplastic syndrome (MDS) risk correlates with advancing age, therapy-induced DNA damage, and/or shorter telomeres, but whether telomere erosion directly induces MDS is unknown. Here, we provide the genetic evidence that...
10.
Klingler S, Guo B, Yao J, Yan H, Zhang L, Vaseva A, et al.
Cancer Res
. 2015 Mar;
75(10):2109-19.
PMID: 25808866
Epidermal growth factor receptor (EGFR) is highly amplified, mutated, and overexpressed in human malignant gliomas. Despite its prevalence and growth-promoting functions, therapeutic strategies to inhibit EGFR kinase activity have not...