Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma

Overview

Journal Cancer Res

Specialty Oncology

Date 2022 May 18

PMID 35584006

Authors

Shawn M Davidson

Daniel R Schmidt

Julia E Heyman

James P OBrien

Amy C Liu

William J Israelsen

Talya L Dayton

Raghav Sehgal

Roderick T Bronson

Elizaveta Freinkman

Howard H Mak

Giuseppe Nicolo Fanelli

Scott Malstrom

Gary Bellinger

Arkaitz Carracedo

Pier Paolo Pandolfi

Kevin D Courtney

Abhishek Jha

Ronald A DePinho

James W Horner

Craig J Thomas

Lewis C Cantley

Massimo Loda

Matthew G Vander Heiden

Affiliations

Soon will be listed here.

Abstract

Differential expression of PKM1 and PKM2 impacts prostate tumorigenesis and suggests a potential therapeutic vulnerability in prostate cancer.

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