Denise J Spring
Overview
Explore the profile of Denise J Spring including associated specialties, affiliations and a list of published articles.
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27
Citations
2233
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Recent Articles
1.
LaBella K, Hsu W, Li J, Qi Y, Liu Y, Liu J, et al.
Dev Cell
. 2024 Apr;
59(11):1475-1486.e5.
PMID: 38574731
Telomere dynamics are linked to aging hallmarks, and age-associated telomere loss fuels the development of epithelial cancers. In Apc-mutant mice, the onset of DNA damage associated with telomere dysfunction has...
2.
Han J, Xu J, Liu Y, Liang S, LaBella K, Chakravarti D, et al.
Genes Dev
. 2023 Sep;
37(17-18):818-828.
PMID: 37775182
Activating KRAS mutations (KRAS*) in pancreatic ductal adenocarcinoma (PDAC) drive anabolic metabolism and support tumor maintenance. KRAS* inhibitors show initial antitumor activity followed by recurrence due to cancer cell-intrinsic and...
3.
Hsu W, LaBella K, Lin Y, Xu P, Lee R, Hsieh C, et al.
Cancer Discov
. 2023 Sep;
13(12):2652-2673.
PMID: 37768068
Significance: This study identified a molecular mechanism contributing to KRAS*-driven colorectal cancer progression via fibroblast transformation in the tumor microenvironment to produce VEGFA driving tumor angiogenesis. In preclinical models, targeting...
4.
Li J, Lan Z, Liao W, Horner J, Xu X, Liu J, et al.
Nature
. 2023 Jun;
619(7970):632-639.
PMID: 37344599
Sex exerts a profound impact on cancer incidence, spectrum and outcomes, yet the molecular and genetic bases of such sex differences are ill-defined and presumptively ascribed to X-chromosome genes and...
5.
Gulhati P, Schalck A, Jiang S, Shang X, Wu C, Hou P, et al.
Nat Cancer
. 2022 Dec;
4(1):62-80.
PMID: 36585453
Pancreatic ductal adenocarcinoma (PDAC) is considered non-immunogenic, with trials showing its recalcitrance to PD1 and CTLA4 immune checkpoint therapies (ICTs). Here, we sought to systematically characterize the mechanisms underlying de...
6.
Lee R, Li J, Li J, Wu C, Jiang S, Hsu W, et al.
Cancer Discov
. 2022 May;
12(7):1702-1717.
PMID: 35537038
Significance: This study identifies critical effectors in the maintenance of APC-deficient colorectal cancer and demonstrates the relationship between APC/WNT pathway and kynurenine pathway signaling. It further determines the tumor-associated macrophage...
7.
Yoshihama Y, LaBella K, Kim E, Bertolet L, Colic M, Li J, et al.
Proc Natl Acad Sci U S A
. 2021 Sep;
118(36).
PMID: 34475205
Prostate cancer is a leading cause of cancer-related mortality in men. The widespread use of androgen receptor (AR) inhibitors has generated an increased incidence of AR-negative prostate cancer, triggering the...
8.
Chakravarti D, Lee R, Multani A, Santoni A, Keith Z, Hsu W, et al.
Proc Natl Acad Sci U S A
. 2021 Jul;
118(29).
PMID: 34253611
Inflammatory bowel disease (IBD) is a chronic inflammatory condition driven by diverse genetic and nongenetic programs that converge to disrupt immune homeostasis in the intestine. We have reported that, in...
9.
Chakravarti D, Hu B, Mao X, Rashid A, Li J, Li J, et al.
Nat Commun
. 2020 Sep;
11(1):4766.
PMID: 32958778
Germline telomere maintenance defects are associated with an increased incidence of inflammatory diseases in humans, yet whether and how telomere dysfunction causes inflammation are not known. Here, we show that...
10.
Zhao D, Cai L, Lu X, Liang X, Li J, Chen P, et al.
Cancer Discov
. 2020 May;
10(9):1374-1387.
PMID: 32385075
Genetic inactivation of is common in prostate cancer and correlates with poorer prognosis. We previously identified as an essential gene in PTEN-deficient cancer cells. Here, we sought definitive genetic evidence...