Jeremy G T Wurtzel
Overview
Explore the profile of Jeremy G T Wurtzel including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
277
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Recent Articles
1.
Del Carpio-Cano F, Songdej N, Guan L, Mao G, Goldfinger L, Wurtzel J, et al.
Res Pract Thromb Haemost
. 2025 Feb;
9(1):102680.
PMID: 39995753
Background: Germline haplodeficiency (RHD) is associated with thrombocytopenia, platelet dysfunction, and predisposition to myeloid malignancies. Platelet expression profiling of an RHD patient showed decreased , encoding for the A subunit...
2.
Lazar S, Wurtzel J, Askari S, Cooper M, Zhao X, Ma P, et al.
Sci Rep
. 2025 Jan;
15(1):3590.
PMID: 39875491
Platelets are enriched in miRNAs and harbor Ago2 as the principal RNA silencing Argonaute. However, roles in thrombopoiesis and platelet function remain poorly understood. We generated megakaryocyte/platelet-specific Ago2-deleted (Ago2 KO)...
3.
Del Carpio-Cano F, Songdej N, Guan L, Mao G, Goldfinger L, Wurtzel J, et al.
medRxiv
. 2025 Jan;
PMID: 39763522
Background: Germline haplodeficiency (RHD) is associated with thrombocytopenia, platelet dysfunction and predisposition to myeloid malignancies. Platelet expression profiling of a RHD patient showed decreased encoding for the A subunit of...
4.
Wurtzel J, Gray B, Pak K, Zhao X, Ma P, McKenzie S, et al.
J Thromb Haemost
. 2024 Oct;
23(1):108-122.
PMID: 39423958
Background: Phosphatidylserine (PS) is a procoagulant phospholipid enriched on surfaces of activated vascular cells including platelets, endothelium, monocytes, and microvesicles. As a molecular driver of thrombosis accessible to drug blockade,...
5.
Wurtzel J, Lazar S, Askari S, Zhao X, Severa J, Ayombil F, et al.
Blood Adv
. 2024 Jan;
8(6):1550-1566.
PMID: 38163324
Mechanisms of proteostasis in anucleate circulating platelets are unknown and may regulate platelet function. We investigated the hypothesis that plasma-borne growth factors/hormones (GFHs) maintain constitutive translation in circulating platelets to...
6.
Wurtzel J, Lazar S, Sikder S, Cai K, Astsaturov I, Weyrich A, et al.
PLoS One
. 2021 Dec;
16(12):e0261633.
PMID: 34936674
We investigated the contributions of platelet microRNAs (miRNAs) to the rate of growth and regulation of gene expression in primary ectopic tumors using mouse models. We previously identified an inhibitory...
7.
Lazar S, Wurtzel J, Chen X, Ma P, Goldfinger L
Platelets
. 2020 Aug;
32(6):794-806.
PMID: 32838617
We sought novel approaches to improve transfection efficiencies of microRNAs (miRNAs) in platelets, and to apply these approaches to investigate the roles of miRNAs in regulating signal-activated protein translation and...
8.
Chen X, Gupta S, Cooper M, DeHelian D, Zhao X, Naik M, et al.
Blood Adv
. 2020 Jan;
4(1):76-86.
PMID: 31899801
G protein-coupled receptors (GPCRs) mediate the majority of platelet activation in response to agonists. However, questions remain regarding the mechanisms that provide negative feedback toward activated GPCRs to limit platelet...
9.
Michael J, Wurtzel J, Mao G, Rao A, Kolpakov M, Sabri A, et al.
Blood
. 2017 May;
130(5):567-580.
PMID: 28500171
Platelet-derived microparticles (PMPs) are associated with enhancement of metastasis and poor cancer outcomes. Circulating PMPs transfer platelet microRNAs (miRNAs) to vascular cells. Solid tumor vasculature is highly permeable, allowing the...
10.
Michael J, Wurtzel J, Goldfinger L
Anticancer Res
. 2016 Nov;
36(10):5053-5061.
PMID: 27798864
The goal of this study was to develop combinatorial application of two drugs currently either in active use as anticancer agents (rapamycin) or in clinical trials (OTX008) as a novel...