James Shorter
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Explore the profile of James Shorter including associated specialties, affiliations and a list of published articles.
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185
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12797
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Recent Articles
11.
Miller L, Shorter J
Cell Chem Biol
. 2024 Jan;
31(1):14-16.
PMID: 38242092
CAG-repeat expansions underlie fatal neurodegenerative disorders. In a lodestar study published in a recent issue of Nature, Sun et al. identify a writer and eraser of N-methyladenosine (mA) modifications of...
12.
Guo L, Mann J, Mauna J, Copley K, Wang H, Rubien J, et al.
bioRxiv
. 2023 Sep;
PMID: 37732211
RNA-binding proteins with prion-like domains, such as FUS and TDP-43, condense into functional liquids, which can transform into pathological fibrils that underpin fatal neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS)/frontotemporal...
13.
Mack K, Kim H, Barbieri E, Lin J, Braganza S, Jackrel M, et al.
Mol Cell
. 2023 Aug;
83(18):3314-3332.e9.
PMID: 37625404
Hsp104 is an AAA+ protein disaggregase that solubilizes and reactivates proteins trapped in aggregated states. We have engineered potentiated Hsp104 variants to mitigate toxic misfolding of α-synuclein, TDP-43, and FUS...
14.
15.
Sharma K, Banerjee S, Savran D, Rajes C, Wiese S, Girdhar A, et al.
J Mol Biol
. 2023 Jul;
435(18):168211.
PMID: 37481159
Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) is a multifunctional RNA-binding protein that is associated with neurodegenerative diseases, such as amyotrophic lateral sclerosis and multisystem proteinopathy. In this study, we have used...
16.
Balendra R, Ruiz de Los Mozos I, Odeh H, Glaria I, Milioto C, Wilson K, et al.
Life Sci Alliance
. 2023 Jul;
6(9).
PMID: 37438085
An intronic GGGGCC repeat expansion in is a common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. The repeats are transcribed in both sense and antisense directions to generate...
17.
Rhine K, Odeh H, Shorter J, Myong S
Chem Rev
. 2023 Apr;
123(14):9065-9093.
PMID: 37115110
Biomolecular condensates are reversible compartments that form through a process called phase separation. Post-translational modifications like ADP-ribosylation can nucleate the formation of these condensates by accelerating the self-association of proteins....
18.
Ervilha Pereira P, Schuermans N, Meylemans A, LeBlanc P, Versluys L, Copley K, et al.
Acta Neuropathol
. 2023 Mar;
145(6):793-814.
PMID: 37000196
Neuronal TDP-43-positive inclusions are neuropathological hallmark lesions in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Pathogenic missense variants in TARDBP, the gene encoding TDP-43, can cause ALS and cluster...
19.
Copley K, Shorter J
Trends Genet
. 2023 Mar;
39(5):381-400.
PMID: 36935218
Repetitive elements (REs), such as transposable elements (TEs) and satellites, comprise much of the genome. Here, we review how TEs and (peri)centromeric satellite DNA may contribute to aging and neurodegenerative...
20.
Boeynaems S, Chong S, Gsponer J, Holt L, Milovanovic D, Mitrea D, et al.
J Mol Biol
. 2023 Jan;
435(5):167971.
PMID: 36690068
In the past almost 15 years, we witnessed the birth of a new scientific field focused on the existence, formation, biological functions, and disease associations of membraneless bodies in cells,...