James M Veal
Overview
Explore the profile of James M Veal including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
22
Citations
616
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Ambrus-Aikelin G, Takeda K, Joetham A, Lazic M, Povero D, Santini A, et al.
Sci Rep
. 2023 Nov;
13(1):20081.
PMID: 37973811
No abstract available.
2.
Ambrus-Aikelin G, Takeda K, Joetham A, Lazic M, Povero D, Santini A, et al.
Sci Rep
. 2023 Aug;
13(1):13524.
PMID: 37598239
The NLRP3 inflammasome is an intracellular, multiprotein complex that promotes the auto-catalytic activation of caspase-1 and the subsequent maturation and secretion of the pro-inflammatory cytokines, IL-1β and IL-18. Persistent activation...
3.
Povero D, Lazic M, McBride C, Ambrus-Aikelin G, Stansfield R, Johnson C, et al.
J Pharmacol Exp Ther
. 2023 Jun;
386(2):242-258.
PMID: 37308266
The NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome is a multiprotein complex and component of the innate immune system that is activated by exogenous and endogenous danger signals to...
4.
Kanouni T, Severin C, Cho R, Yuen N, Xu J, Shi L, et al.
J Med Chem
. 2020 Oct;
63(23):14522-14529.
PMID: 33034194
Histone demethylase LSDl (KDMlA) belongs to the flavin adenine dinucleotide (FAD) dependent family of monoamine oxidases and is vital in regulation of mammalian biology. Dysregulation and overexpression of LSD1 are...
5.
Nie Z, Shi L, Lai C, Severin C, Xu J, Del Rosario J, et al.
Bioorg Med Chem Lett
. 2018 Nov;
29(1):103-106.
PMID: 30409536
The histone demethylase LSD1 is a key enzyme in the epigenetic regulation of gene transcription. Here we present our efforts to discover small molecule reversible inhibitors of LSD1 as an...
6.
Bennett M, Wu Y, Boloor A, Matuszkiewicz J, OConnell S, Shi L, et al.
Bioorg Med Chem Lett
. 2018 Apr;
28(10):1811-1816.
PMID: 29657099
The bromodomain and extra-terminal (BET) family of epigenetic proteins has attracted considerable attention in drug discovery given its involvement in regulating gene transcription. Screening a focused small molecule library based...
7.
Nie Z, Shi L, Lai C, OConnell S, Xu J, Stansfield R, et al.
Bioorg Med Chem Lett
. 2018 Apr;
28(9):1490-1494.
PMID: 29627262
Histone lysine demethylases (KDMs) play a key role in epigenetic regulation and KDM5A and KDM5B have been identified as potential anti-cancer drug targets. Using structural information from known KDM4 and...
8.
Chen Y, Bonaldi T, Cuomo A, Del Rosario J, Hosfield D, Kanouni T, et al.
ACS Med Chem Lett
. 2017 Aug;
8(8):869-874.
PMID: 28835804
Histone lysine demethylases (KDMs) play a vital role in the regulation of chromatin-related processes. Herein, we describe our discovery of a series of potent KDM4 inhibitors that are both cell...
9.
Carlson D, Franke A, Weitzel D, Speer B, Hughes P, Hagerty L, et al.
ACS Chem Biol
. 2013 Sep;
8(12):2715-23.
PMID: 24070067
DAPK1 and ZIPK (also called DAPK3) are closely related serine/threonine protein kinases that regulate programmed cell death and phosphorylation of non-muscle and smooth muscle myosin. We have developed a fluorescence...
10.
Huang K, Barta T, Rice J, Smith E, Ommen A, Ma W, et al.
Bioorg Med Chem Lett
. 2012 Mar;
22(7):2550-4.
PMID: 22386527
A novel class of Hsp90 inhibitors, structurally distinct from previously reported scaffolds, was developed from rational design and optimization of a compound library screen hit. These aminoquinazoline derivatives, represented by...