Steven E Hall
Overview
Explore the profile of Steven E Hall including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
187
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Recent Articles
1.
Huang K, Barta T, Rice J, Smith E, Ommen A, Ma W, et al.
Bioorg Med Chem Lett
. 2012 Mar;
22(7):2550-4.
PMID: 22386527
A novel class of Hsp90 inhibitors, structurally distinct from previously reported scaffolds, was developed from rational design and optimization of a compound library screen hit. These aminoquinazoline derivatives, represented by...
2.
Fadden P, Huang K, Veal J, Steed P, Barabasz A, Foley B, et al.
Chem Biol
. 2010 Jul;
17(7):686-94.
PMID: 20659681
A chemoproteomics-based drug discovery strategy is presented that utilizes a highly parallel screening platform, encompassing more than 1000 targets, with a focused chemical library prior to target selection. This chemoproteomics-based...
3.
Huang K, Veal J, Fadden R, Rice J, Eaves J, Strachan J, et al.
J Med Chem
. 2009 Jun;
52(14):4288-305.
PMID: 19552433
A novel class of heat shock protein 90 (Hsp90) inhibitors was developed from an unbiased screen to identify protein targets for a diverse compound library. These indol-4-one and indazol-4-one derived...
4.
Barta T, Barabasz A, Foley B, Geng L, Hall S, Hanson G, et al.
Bioorg Med Chem Lett
. 2009 Apr;
19(11):3078-80.
PMID: 19394222
In the course of our Heat Shock 90 program, certain carbazole compounds were identified which had an off-target antiproliferative activity. To understand the off-target activity, we studied one analog with...
5.
Rice J, Veal J, Fadden R, Barabasz A, Partridge J, Barta T, et al.
Arthritis Rheum
. 2008 Nov;
58(12):3765-75.
PMID: 19035474
Objective: To evaluate the ability of SNX-7081, a novel small molecule inhibitor of Hsp90, to block components of inflammation, including cytokine production, protein kinase activity, and angiogenic signaling. A close...
6.
Barta T, Veal J, Rice J, Partridge J, Fadden R, Ma W, et al.
Bioorg Med Chem Lett
. 2008 May;
18(12):3517-21.
PMID: 18511277
Hsp90 maintains the conformational stability of multiple proteins implicated in oncogenesis and has emerged as a target for chemotherapy. We report here the discovery of a novel small molecule scaffold...
7.
Hall S
Drug Discov Today
. 2006 May;
11(11-12):495-502.
PMID: 16713900
The advent of multiple high-throughput technologies has brought drug discovery round almost full circle, from pharmacological testing of compounds in vivo to engineered molecular target assays and back to integrated...
8.
Lampe J, Biggers C, Defauw J, Foglesong R, Hall S, Heerding J, et al.
J Med Chem
. 2002 May;
45(12):2624-43.
PMID: 12036372
A series of analogues of the protein kinase C (PKC) inhibitory natural product balanol which bear modified benzophenone subunits are described. The analogues were designed with the goal of uncovering...
9.
Das J, Kimball S, Hall S, Han W, Iwanowicz E, Lin J, et al.
Bioorg Med Chem Lett
. 2001 Dec;
12(1):45-9.
PMID: 11738570
A series of structurally novel small molecule inhibitors of human alpha-thrombin was prepared to elucidate their structure-activity relationships (SARs), selectivity and activity in vivo. BMS-189664 (3) is identified as a...