James M Murithi
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Explore the profile of James M Murithi including associated specialties, affiliations and a list of published articles.
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12
Citations
385
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Recent Articles
1.
Arendse L, Murithi J, Qahash T, Pasaje C, Godoy L, Dey S, et al.
Sci Transl Med
. 2022 Oct;
14(667):eabo7219.
PMID: 36260689
Compounds acting on multiple targets are critical to combating antimalarial drug resistance. Here, we report that the human "mammalian target of rapamycin" (mTOR) inhibitor sapanisertib has potent prophylactic liver stage...
2.
Qiu D, Pei J, Rosling J, Thathy V, Li D, Xue Y, et al.
Nat Commun
. 2022 Sep;
13(1):5746.
PMID: 36180431
Diverse compounds target the Plasmodium falciparum Na pump PfATP4, with cipargamin and (+)-SJ733 the most clinically-advanced. In a recent clinical trial for cipargamin, recrudescent parasites emerged, with most having a...
3.
Summers R, Pasaje C, Pisco J, Striepen J, Luth M, Kumpornsin K, et al.
Cell Chem Biol
. 2021 Aug;
29(2):191-201.e8.
PMID: 34348113
We identify the Plasmodium falciparum acetyl-coenzyme A synthetase (PfAcAS) as a druggable target, using genetic and chemical validation. In vitro evolution of resistance with two antiplasmodial drug-like compounds (MMV019721 and...
4.
Murithi J, Pascal C, Bath J, Boulenc X, Gnadig N, Pasaje C, et al.
Sci Transl Med
. 2021 Jul;
13(603).
PMID: 34290058
The emergence and spread of resistance to first-line antimalarials creates an imperative to identify and develop potent preclinical candidates with distinct modes of action. Here, we report the identification of...
5.
Murithi J, Deni I, Pasaje C, Okombo J, Bridgford J, Gnadig N, et al.
Cell Chem Biol
. 2021 Jul;
29(5):824-839.e6.
PMID: 34233174
Widespread Plasmodium falciparum resistance to first-line antimalarials underscores the vital need to develop compounds with novel modes of action and identify new druggable targets. Here, we profile five compounds that...
6.
Miguel-Blanco C, Murithi J, Diez Benavente E, Angrisano F, Sala K, van Schalkwyk D, et al.
Sci Rep
. 2021 Jan;
11(1):1888.
PMID: 33479319
New antimalarial therapeutics are needed to ensure that malaria cases continue to be driven down, as both emerging parasite resistance to frontline chemotherapies and mosquito resistance to current insecticides threaten...
7.
Vanaerschot M, Murithi J, Pasaje C, Ghidelli-Disse S, Dwomoh L, Bird M, et al.
Cell Chem Biol
. 2020 May;
27(7):806-816.e8.
PMID: 32359426
The search for antimalarial chemotypes with modes of action unrelated to existing drugs has intensified with the recent failure of first-line therapies across Southeast Asia. Here, we show that the...
8.
Murithi J, Owen E, Istvan E, Lee M, Ottilie S, Chibale K, et al.
Cell Chem Biol
. 2019 Dec;
27(2):158-171.e3.
PMID: 31813848
We report detailed susceptibility profiling of asexual blood stages of the malaria parasite Plasmodium falciparum to clinical and experimental antimalarials, combined with metabolomic fingerprinting. Results revealed a variety of stage-specific...
9.
Stokes B, Yoo E, Murithi J, Luth M, Afanasyev P, da Fonseca P, et al.
PLoS Pathog
. 2019 Jun;
15(6):e1007722.
PMID: 31170268
Therapeutics with novel modes of action and a low risk of generating resistance are urgently needed to combat drug-resistant Plasmodium falciparum malaria. Here, we report that the peptide vinyl sulfones...
10.
Cowell A, Istvan E, Lukens A, Gomez-Lorenzo M, Vanaerschot M, Sakata-Kato T, et al.
Science
. 2018 Jan;
359(6372):191-199.
PMID: 29326268
Chemogenetic characterization through in vitro evolution combined with whole-genome analysis can identify antimalarial drug targets and drug-resistance genes. We performed a genome analysis of 262 parasites resistant to 37 diverse...