Joseph J Belanto
Overview
Explore the profile of Joseph J Belanto including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
15
Citations
1428
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0
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Recent Articles
1.
Randazzo D, Khalique U, Belanto J, Kenea A, Talsness D, Olthoff J, et al.
Hum Mol Genet
. 2019 Feb;
28(11):1930.
PMID: 30753428
No abstract available.
2.
Randazzo D, Khalique U, Belanto J, Kenea A, Talsness D, Olthoff J, et al.
Hum Mol Genet
. 2018 Dec;
28(7):1117-1135.
PMID: 30535187
In healthy adult skeletal muscle fibers microtubules form a three-dimensional grid-like network. In the mdx mouse, a model of Duchenne muscular dystrophy (DMD), microtubules are mostly disordered, without periodicity. These...
3.
Olthoff J, Lindsay A, Abo-Zahrah R, Baltgalvis K, Patrinostro X, Belanto J, et al.
Nat Commun
. 2018 Dec;
9(1):5104.
PMID: 30504831
Force loss in skeletal muscle exposed to eccentric contraction is often attributed to injury. We show that EDL muscles from dystrophin-deficient mdx mice recover 65% of lost force within 120 ...
4.
McCourt J, Talsness D, Lindsay A, Arpke R, Chatterton P, Nelson D, et al.
Hum Mol Genet
. 2017 Dec;
27(3):451-462.
PMID: 29194514
Missense mutations in the dystrophin protein can cause Duchenne muscular dystrophy (DMD) or Becker muscular dystrophy (BMD) through an undefined pathomechanism. In vitro studies suggest that missense mutations in the...
5.
Abudayyeh O, Gootenberg J, Essletzbichler P, Han S, Joung J, Belanto J, et al.
Nature
. 2017 Oct;
550(7675):280-284.
PMID: 28976959
RNA has important and diverse roles in biology, but molecular tools to manipulate and measure it are limited. For example, RNA interference can efficiently knockdown RNAs, but it is prone...
6.
cermak T, Curtin S, Gil-Humanes J, Cegan R, Kono T, Konecna E, et al.
Plant Cell
. 2017 May;
29(6):1196-1217.
PMID: 28522548
We report a comprehensive toolkit that enables targeted, specific modification of monocot and dicot genomes using a variety of genome engineering approaches. Our reagents, based on transcription activator-like effector nucleases...
7.
Belanto J, Olthoff J, Mader T, Chamberlain C, Nelson D, McCourt P, et al.
Hum Mol Genet
. 2017 Feb;
25(22):4951-4961.
PMID: 28171583
Absence of the protein dystrophin causes Duchenne muscular dystrophy. Dystrophin directly binds to microtubules in vitro, and its absence in vivo correlates with disorganization of the subsarcolemmal microtubule lattice, increased...
8.
Osborn M, Belanto J, Tolar J, Voytas D
Int J Hematol
. 2016 May;
104(1):18-28.
PMID: 27233509
The use of precise, rationally designed gene-editing nucleases allows for targeted genome and transcriptome modification, and at present, four major classes of nucleases are being employed: zinc finger nucleases (ZFNs),...
9.
Filareto A, Rinaldi F, Arpke R, Darabi R, Belanto J, Toso E, et al.
Skelet Muscle
. 2015 Oct;
5:36.
PMID: 26504514
Background: Satellite cells (SCs) are indispensable for muscle regeneration and repair; however, due to low frequency in primary muscle and loss of engraftment potential after ex vivo expansion, their use...
10.
Talsness D, Belanto J, Ervasti J
Proc Natl Acad Sci U S A
. 2015 Sep;
112(40):12414-9.
PMID: 26392559
The 427-kDa protein dystrophin is expressed in striated muscle where it physically links the interior of muscle fibers to the extracellular matrix. A range of mutations in the DMD gene...