James M Dewar
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Explore the profile of James M Dewar including associated specialties, affiliations and a list of published articles.
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22
Citations
724
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Recent Articles
1.
Cranford M, Dahmen S, Cortez D, Dewar J
bioRxiv
. 2025 Jan;
PMID: 39829849
Abasic sites are one of the most frequent forms of DNA damage that interfere with DNA replication. However, abasic sites exhibit complex effects because they can be processed into other...
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Vontalge E, Kavlashvili T, Dahmen S, Cranford M, Dewar J
Nat Protoc
. 2024 Apr;
19(7):1940-1983.
PMID: 38594502
A major obstacle to studying DNA replication is that it involves asynchronous and highly delocalized events. A reversible replication barrier overcomes this limitation and allows replication fork movement to be...
4.
Campos L, Van Ravenstein S, Vontalge E, Greer B, Heintzman D, Kavlashvili T, et al.
Cell Rep
. 2023 Feb;
42(2):112109.
PMID: 36807139
Topological stress can cause converging replication forks to stall during termination of vertebrate DNA synthesis. However, replication forks ultimately overcome fork stalling, suggesting that alternative mechanisms of termination exist. Using...
5.
Kavlashvili T, Liu W, Mohamed T, Cortez D, Dewar J
Nat Struct Mol Biol
. 2023 Jan;
30(1):115-124.
PMID: 36593312
Genotoxins cause nascent strand degradation (NSD) and fork reversal during DNA replication. NSD and fork reversal are crucial for genome stability and are exploited by chemotherapeutic approaches. However, it is...
6.
Conwell S, Cranford M, Kavlashvili T, Dewar J
Methods Enzymol
. 2022 Aug;
672:317-338.
PMID: 35934482
When a replication fork encounters a nick in the parental DNA, the replisome dissociates and the replication fork structure is lost. This outcome is referred to as replication fork "collapse."...
7.
Van Ravenstein S, Mehta K, Kavlashvili T, Byl J, Zhao R, Osheroff N, et al.
EMBO J
. 2022 May;
41(12):e110632.
PMID: 35578785
Topoisomerase II (TOP2) unlinks chromosomes during vertebrate DNA replication. TOP2 "poisons" are widely used chemotherapeutics that stabilize TOP2 complexes on DNA, leading to cytotoxic DNA breaks. However, it is unclear...
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Kavlashvili T, Dewar J
Methods Mol Biol
. 2022 Mar;
2444:105-123.
PMID: 35290634
DNA replication is crucial for cell viability and genome integrity. Despite its crucial role in genome duplication, the final stage of DNA replication, which is termed termination, is relatively unexplored....
10.
Vrtis K, Dewar J, Chistol G, Wu R, Graham T, Walter J
Mol Cell
. 2021 Jan;
81(6):1309-1318.e6.
PMID: 33484638
DNA damage impedes replication fork progression and threatens genome stability. Upon encounter with most DNA adducts, the replicative CMG helicase (CDC45-MCM2-7-GINS) stalls or uncouples from the point of synthesis, yet...