Matthew T Cranford
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Explore the profile of Matthew T Cranford including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
19
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Recent Articles
1.
Cranford M, Dahmen S, Cortez D, Dewar J
bioRxiv
. 2025 Jan;
PMID: 39829849
Abasic sites are one of the most frequent forms of DNA damage that interfere with DNA replication. However, abasic sites exhibit complex effects because they can be processed into other...
2.
Vontalge E, Kavlashvili T, Dahmen S, Cranford M, Dewar J
Nat Protoc
. 2024 Apr;
19(7):1940-1983.
PMID: 38594502
A major obstacle to studying DNA replication is that it involves asynchronous and highly delocalized events. A reversible replication barrier overcomes this limitation and allows replication fork movement to be...
3.
Conwell S, Cranford M, Kavlashvili T, Dewar J
Methods Enzymol
. 2022 Aug;
672:317-338.
PMID: 35934482
When a replication fork encounters a nick in the parental DNA, the replisome dissociates and the replication fork structure is lost. This outcome is referred to as replication fork "collapse."...
4.
Cranford M, Kaszubowski J, Trakselis M
Nucleic Acids Res
. 2020 Sep;
48(19):10986-10997.
PMID: 32997110
During DNA replication, the presence of 8-oxoguanine (8-oxoG) lesions in the template strand cause the high-fidelity (HiFi) DNA polymerase (Pol) to stall. An early response to 8-oxoG lesions involves 'on-the-fly'...
5.
Trakselis M, Cranford M, Chu A
Chem Res Toxicol
. 2017 Sep;
30(11):1956-1971.
PMID: 28881136
The ability for DNA polymerases (Pols) to overcome a variety of obstacles in its path to maintain genomic stability during replication is a complex endeavor. It requires the coordination of...
6.
Cranford M, Chu A, Baguley J, Bauer R, Trakselis M
Nucleic Acids Res
. 2017 Jun;
45(14):8329-8340.
PMID: 28655184
The ability of the replisome to seamlessly coordinate both high fidelity and translesion DNA synthesis requires a means to regulate recruitment and binding of enzymes from solution. Co-occupancy of multiple...