James L Keck
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Explore the profile of James L Keck including associated specialties, affiliations and a list of published articles.
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101
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2848
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Recent Articles
1.
Zhang Z, Lettman M, Schuh A, Bhattacharyya B, Randolph P, Nandakumar T, et al.
bioRxiv
. 2024 Nov;
PMID: 39574627
Pathological variants in Trk-fused gene (TFG) have been implicated in a variety of neurodegenerative conditions. In particular, mutations within its amino-terminal PB1 domain have been suggested to cause hereditary spastic...
2.
Koo A, Jia W, Kim S, Scalf M, Boos C, Chen Y, et al.
bioRxiv
. 2024 Nov;
PMID: 39553946
RIF1 (RAP1 interacting factor) fulfills diverse roles in DNA double-strand break repair, DNA replication, and nuclear organization. RIF1 is expressed as two splice variants, RIF1-Long (RIF1-L) and RIF1-Short (RIF1-S), from...
3.
Cueny R, Voter A, McKenzie A, Morgenstern M, Myers K, Place M, et al.
bioRxiv
. 2024 Aug;
PMID: 39185182
G-quadruplex (G4) structures can form in guanine-rich DNA or RNA and have been found to modulate cellular processes including replication, transcription, and translation. Many studies on the cellular roles of...
4.
Bonde N, Kozlov A, Cox M, Lohman T, Keck J
Crit Rev Biochem Mol Biol
. 2024 May;
59(1-2):99-127.
PMID: 38770626
The SSB protein of functions to bind single-stranded DNA wherever it occurs during DNA metabolism. Depending upon conditions, SSB occurs in several different binding modes. In the course of its...
5.
Sung A, Guerra R, Steenberge L, Alston C, Murayama K, Okazaki Y, et al.
Nat Metab
. 2024 May;
6(6):1128-1142.
PMID: 38720117
Isolated complex I (CI) deficiencies are a major cause of primary mitochondrial disease. A substantial proportion of CI deficiencies are believed to arise from defects in CI assembly factors (CIAFs)...
6.
McMillan S, Keck J
J Biol Chem
. 2024 Apr;
300(5):107275.
PMID: 38588814
DNA replication in Escherichia coli starts with loading of the replicative helicase, DnaB, onto DNA. This reaction requires the DnaC loader protein, which forms a 6:6 complex with DnaB and...
7.
Sandler S, Bonde N, Wood E, Cox M, Keck J
J Bacteriol
. 2024 Mar;
206(4):e0033023.
PMID: 38470036
Tetrameric single-stranded (ss) DNA-binding proteins (SSBs) stabilize ssDNA intermediates formed during genome maintenance reactions in . SSBs also recruit proteins important for these processes through direct SSB-protein interactions, including proteins...
8.
Bonde N, Wood E, Myers K, Place M, Keck J, Cox M
J Bacteriol
. 2023 Nov;
205(12):e0018423.
PMID: 38019006
DNA damage and subsequent DNA repair processes are mutagenic in nature and an important driver of evolution in prokaryotes, including antibiotic resistance development. Genetic screening approaches, such as transposon sequencing...
9.
Alnammi M, Liu S, Ericksen S, Ananiev G, Voter A, Guo S, et al.
J Chem Inf Model
. 2023 Aug;
63(17):5513-5528.
PMID: 37625010
Traditional small-molecule drug discovery is a time-consuming and costly endeavor. High-throughput chemical screening can only assess a tiny fraction of drug-like chemical space. The strong predictive power of modern machine-learning...
10.
Cueny R, Varma S, Schmidt K, Keck J
PLoS One
. 2023 Jun;
18(6):e0281524.
PMID: 37267408
Bloom syndrome helicase (BLM) is a RecQ-family helicase implicated in a variety of cellular processes, including DNA replication, DNA repair, and telomere maintenance. Mutations in human BLM cause Bloom syndrome...