James J Lu
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Explore the profile of James J Lu including associated specialties, affiliations and a list of published articles.
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20
Citations
504
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Recent Articles
1.
Lu J, Polgar W, Mann A, Dasgupta P, Schulz S, Zaveri N
Mol Pharmacol
. 2021 May;
100(1):7-18.
PMID: 33958480
Agonists at the nociceptin opioid peptide receptor (NOP) are under investigation as therapeutics for nonaddicting analgesia, opioid use disorder, Parkinson's disease, and other indications. NOP full and partial agonists have...
2.
Ding H, Kiguchi N, Yasuda D, Daga P, Polgar W, Lu J, et al.
Sci Transl Med
. 2018 Aug;
10(456).
PMID: 30158150
Misuse of prescription opioids, opioid addiction, and overdose underscore the urgent need for developing addiction-free effective medications for treating severe pain. Mu opioid peptide (MOP) receptor agonists provide very effective...
3.
Zheng S, Jabbour S, OReilly S, Lu J, Dong L, Ding L, et al.
JMIR Med Inform
. 2018 Feb;
6(1):e8.
PMID: 29391345
Background: In outcome studies of oncology patients undergoing radiation, researchers extract valuable information from medical records generated before, during, and after radiotherapy visits, such as survival data, toxicities, and complications....
4.
Dantes R, Zheng S, Lu J, Beckman M, Krishnaswamy A, Richardson L, et al.
Med Care
. 2017 Nov;
56(9):e54-e60.
PMID: 29087984
Introduction: The United States federally mandated reporting of venous thromboembolism (VTE), defined by Agency for Healthcare Research & Quality Patient Safety Indicator 12 (AHRQ PSI-12), is based on administrative data,...
5.
Zheng S, Lu J, Ghasemzadeh N, Hayek S, Quyyumi A, Wang F
JMIR Med Inform
. 2017 May;
5(2):e12.
PMID: 28487265
Background: Extracting structured data from narrated medical reports is challenged by the complexity of heterogeneous structures and vocabularies and often requires significant manual effort. Traditional machine-based approaches lack the capability...
6.
Zheng S, Lu J, Appin C, Brat D, Wang F
J Pathol Inform
. 2015 Nov;
6:51.
PMID: 26605116
Background: Structural reporting enables semantic understanding and prompt retrieval of clinical findings about patients. While synoptic pathology reporting provides templates for data entries, information in pathology reports remains primarily in...
7.
Zheng S, Wang F, Lu J
AMIA Annu Symp Proc
. 2014 Feb;
2013:1590-9.
PMID: 24551429
To facilitate the process of extracting information from narrative medical reports and transforming extracted data into standardized structured forms, we present an interactive, incrementally learning based information extraction system -...
8.
Lu J, Langer R, Chen J
Mol Pharm
. 2009 Mar;
6(3):763-71.
PMID: 19292453
A key challenge for therapeutic application of RNA interference is to efficiently deliver synthetic small interfering RNAs (siRNAs) into target cells that will lead to the knockdown of the target...
9.
Hu Y, Atukorale P, Lu J, Moon J, Um S, Cho E, et al.
Biomacromolecules
. 2009 Feb;
10(4):756-65.
PMID: 19239276
We recently described a strategy for intracellular delivery of macromolecules, utilizing pH-responsive "core-shell" structured gel particles. These cross-linked hydrogel particles disrupt endosomes with low toxicity by virtue of physical sequestration...
10.
Jurczyk P, Lu J, Xiong L, Cragan J, Correa A
AMIA Annu Symp Proc
. 2008 Nov;
:440-4.
PMID: 18998844
A fine-grained record integration and linkage tool (FRIL) is presented. The tool extends traditional record linkage tools with a richer set of parameters. Users may systematically and iteratively explore the...