James J Champoux
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Explore the profile of James J Champoux including associated specialties, affiliations and a list of published articles.
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31
Citations
1011
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Recent Articles
1.
Interthal H, Champoux J
Biochem J
. 2011 Apr;
436(3):559-66.
PMID: 21463258
TDP (tyrosyl-DNA phosphodiesterase) 1 catalyses the hydrolysis of phosphodiester linkages between a DNA 3' phosphate and a tyrosine residue as well as a variety of other DNA 3' substituents, and...
2.
Multiple nucleotide preferences determine cleavage-site recognition by the HIV-1 and M-MuLV RNases H
Schultz S, Zhang M, Champoux J
J Mol Biol
. 2010 Feb;
397(1):161-78.
PMID: 20122939
The RNase H activity of reverse transcriptase is required during retroviral replication and represents a potential target in antiviral drug therapies. Sequence features flanking a cleavage site influence the three...
3.
Schultz S, Zhang M, Champoux J
J Biol Chem
. 2009 Sep;
284(47):32225-38.
PMID: 19778906
The RNase H activity of reverse transcriptase carries out three types of cleavage termed internal, RNA 5' end-directed, and DNA 3' end-directed. Given the strong association between the polymerase domain...
4.
Yang Z, Champoux J
Methods Mol Biol
. 2009 Sep;
582:49-57.
PMID: 19763941
To assay the preferential binding of eukaryotic type IB topoisomerases to supercoiled DNA, two methods are described that make use of a catalytically inactive mutant form of the enzyme. In...
5.
Yang Z, Carey J, Champoux J
FEBS J
. 2009 Sep;
276(20):5906-19.
PMID: 19740104
Human topoisomerase I binds DNA in a topology-dependent fashion with a strong preference for supercoiled DNAs of either sign over relaxed circular DNA. One hypothesis to account for this preference...
6.
Champoux J, Schultz S
FEBS J
. 2009 Feb;
276(6):1506-16.
PMID: 19228195
Retroviral reverse transcriptases possess both a DNA polymerase and an RNase H activity. The linkage with the DNA polymerase activity endows the retroviral RNases H with unique properties not found...
7.
Kim H, Cardellina 2nd J, Akee R, Champoux J, Stivers J
Bioorg Chem
. 2008 May;
36(4):190-7.
PMID: 18508107
Human topoisomerase IB (hTopo) forms a covalent phosphotyrosyl linkage with the DNA backbone, and controls genomic DNA topology by relaxing DNA supercoils during the processes of DNA replication, transcription, chromosome...
8.
Schultz S, Champoux J
Virus Res
. 2008 Feb;
134(1-2):86-103.
PMID: 18261820
This review compares the well-studied RNase H activities of human immunodeficiency virus, type 1 (HIV-1) and Moloney murine leukemia virus (MoMLV) reverse transcriptases. The RNase H domains of HIV-1 and...
9.
Hirano R, Interthal H, Huang C, Nakamura T, Deguchi K, Choi K, et al.
EMBO J
. 2007 Oct;
26(22):4732-43.
PMID: 17948061
Tyrosyl-DNA phosphodiesterase 1 (Tdp1) cleaves the phosphodiester bond between a covalently stalled topoisomerase I (Topo I) and the 3' end of DNA. Stalling of Topo I at DNA strand breaks...
10.
Paulson B, Zhang M, Schultz S, Champoux J
Virology
. 2007 May;
366(2):361-76.
PMID: 17532359
A distinctive property of reverse transcriptase is the ability to carry out strand displacement synthesis in the absence of accessory proteins such as helicases or single-strand DNA binding proteins. Structure-function...