James J Bieker
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Explore the profile of James J Bieker including associated specialties, affiliations and a list of published articles.
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65
Citations
1902
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Recent Articles
1.
Xue L, Mukherjee K, Kelley K, Bieker J
Front Hematol
. 2024 Sep;
2.
PMID: 39280931
Introduction: EKLF/Klf1 is a tissue-restricted transcription factor that plays a critical role in all aspects of erythropoiesis. Of particular note is its tissue-restricted pattern of expression, a property that could...
2.
Bieker J, Philipsen S
Adv Exp Med Biol
. 2024 Jul;
1459:217-242.
PMID: 39017846
Erythroid Krüppel-like factor (KLF1), first discovered in 1992, is an erythroid-restricted transcription factor (TF) that is essential for terminal differentiation of erythroid progenitors. At face value, KLF1 is a rather...
3.
Chen X, Pillay S, Lohmann F, Bieker J
J Biol Chem
. 2023 Nov;
299(12):105489.
PMID: 38000658
EKLF/KLF1 is an essential transcription factor that plays a global role in erythroid transcriptional activation. Regulation of KLF1 is of interest, as it displays a highly restricted expression pattern, limited...
4.
May A, Ventura T, Fidanza A, Volmer H, Taylor H, Romano N, et al.
Front Cell Dev Biol
. 2023 Apr;
11:1148013.
PMID: 37113767
Congenital dyserythropoietic anaemia (CDA) type IV has been associated with an amino acid substitution, Glu325Lys (E325K), in the transcription factor KLF1. These patients present with a range of symptoms, including...
5.
Ferrer-Vicens I, Ferguson D, Wilson M, Heesom K, Bieker J, Frayne J
Blood
. 2023 Apr;
141(25):3039-3054.
PMID: 37084386
Red blood cell disorders can result in severe anemia. One such disease congenital dyserythropoietic anemia IV (CDA IV) is caused by the heterozygous mutation E325K in the transcription factor KLF1....
6.
Mukherjee K, Bieker J
Cell Rep
. 2022 Dec;
41(12):111830.
PMID: 36543143
EKLF/Klf1 is a zinc-finger transcription activator essential for erythroid lineage commitment and terminal differentiation. Using ChIP-seq, we investigate EKLF DNA binding and transcription activation mechanisms during mouse embryonic erythropoiesis. We...
7.
Varricchio L, Geer E, Martelli F, Mazzarini M, Funnell A, Bieker J, et al.
Haematologica
. 2022 Jul;
108(4):1053-1067.
PMID: 35861015
Although human cell cultures stimulated with dexamethasone suggest that the glucocorticoid receptor (GR) activates stress erythropoiesis, the effects of GR activation on erythropoiesis in vivo remain poorly understood. We characterized...
8.
Mukherjee K, Bieker J
Bio Protoc
. 2022 Mar;
12(3):e4329.
PMID: 35284601
[This corrects the article DOI: 10.21769/BioProtoc.4243.].
9.
Mukherjee K, Bieker J
Bio Protoc
. 2022 Jan;
11(23):e4243.
PMID: 35005088
erythropoiesis occurs in the erythroblast island niche (EBI), comprising of a central macrophage that attaches to and aids the maturation of erythroid progenitors into mature reticulocytes. Macrophages in hematopoietic tissue...
10.
Mukherjee K, Bieker J
Front Genet
. 2021 Dec;
12:756028.
PMID: 34880902
During definitive erythropoiesis, maturation of erythroid progenitors into enucleated reticulocytes requires the erythroblastic island (EBI) niche comprising a central macrophage attached to differentiating erythroid progenitors. Normally, the macrophage provides a...