James I Austerberry
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Explore the profile of James I Austerberry including associated specialties, affiliations and a list of published articles.
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5
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46
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Recent Articles
1.
Austerberry J, Thistlethwaite A, Fisher K, Golovanov A, Pluen A, Esfandiary R, et al.
Biochemistry
. 2019 Jul;
58(32):3413-3421.
PMID: 31314511
Increased protein solubility is known to correlate with an increase in the proportion of lysine over arginine residues. Previous work has shown that the aggregation propensity of a single-chain variable...
2.
Eyes T, Austerberry J, Dearman R, Johannissen L, Kimber I, Smith N, et al.
Mol Immunol
. 2018 Dec;
105:181-189.
PMID: 30550980
Aggregation of therapeutic proteins is a key factor in the generation of unwanted immunogenicity, and can result in reduced serum half-life, neutralization of function and adverse health effects. There is...
3.
Austerberry J, Belton D
3 Biotech
. 2017 Mar;
6(1):33.
PMID: 28330101
Large-scale expression of biopharmaceutical proteins in cellular hosts results in production of large insoluble mass aggregates. In order to generate functional product, these aggregates require further processing through refolding with...
4.
Austerberry J, Dajani R, Panova S, Roberts D, Golovanov A, Pluen A, et al.
Eur J Pharm Biopharm
. 2017 Feb;
115:18-30.
PMID: 28161552
The aggregation propensities for a series of single-chain variable fragment (scFv) mutant proteins containing supercharged sequences, salt bridges and lysine/arginine-enriched motifs were characterised as a function of pH and ionic...
5.
Jones A, Austerberry J, Dajani R, Warwicker J, Curtis R, Derrick J, et al.
Biochim Biophys Acta
. 2016 Sep;
1863(12):3116-3124.
PMID: 27619192
The Tat system transports folded proteins across the bacterial plasma membrane, and in Escherichia coli preferentially transports correctly-folded proteins. Little is known of the mechanism by which Tat proofreads a...