Alexander P Golovanov
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Explore the profile of Alexander P Golovanov including associated specialties, affiliations and a list of published articles.
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61
Citations
960
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Recent Articles
1.
Bentley K, Hareram M, Wang G, Millman A, Perez-Ortega I, Nichols L, et al.
J Am Chem Soc
. 2025 Feb;
147(6):5035-5042.
PMID: 39901642
Bis-cycloruthenated complexes (BCRCs) of the type [Ru(N^C)L] are proposed to be key reactive intermediates in the Ru(II)-catalyzed directed C-H functionalization of arenes. While the exceptional ground state reactivity of BCRCs...
2.
Mukhopadhyay A, Li Y, Cliff M, Golovanov A, Dalby P
Sci Rep
. 2024 Nov;
14(1):28080.
PMID: 39543195
We have previously engineered E. coli transketolase (TK) enzyme variants that accept new substrates such as aliphatic or aromatic aldehydes, and also with improved thermal stability. Irreversible aggregation is the...
3.
Bramham J, Wang Y, Moore S, Golovanov A
Anal Chem
. 2024 Jun;
96(24):9935-9943.
PMID: 38847283
Biopharmaceuticals, such as monoclonal antibodies (mAbs), need to maintain their chemical and physical stability in formulations throughout their lifecycle. It is known that exposure of mAbs to light, particularly UV,...
4.
Eastham K, Kennedy A, Scottwell S, Bramham J, Hardman S, Golovanov A, et al.
Inorg Chem
. 2024 May;
63(20):9084-9097.
PMID: 38701516
Photochemical ligand release from metal complexes may be exploited in the development of novel photoactivated chemotherapy agents for the treatment of cancer and other diseases. Highly intriguing photochemical behavior is...
5.
Woodward A, Bramham J, Brookfield A, Golovanov A, Bowen A
Chem Commun (Camb)
. 2024 Jan;
60(8):1012-1015.
PMID: 38170515
Illumination into an electron paramagnetic resonance (EPR) spectrometer is commonly carried out through the optical window, perpendicular to the sample and magnetic field. Here we show that significant improvements can...
6.
Smith M, Bramham J, Nilsson M, Morris G, Castanar L, Golovanov A
Chem Commun (Camb)
. 2023 Sep;
59(78):11692-11695.
PMID: 37698544
Fluorine is becoming increasingly prevalent in medicinal chemistry, both in drug molecules and in molecular probes. The presence of fluorine allows convenient monitoring of such molecules in complex environments by...
7.
Kulakova A, Augustijn D, El Bialy I, Gentiluomo L, Greco M, Hervo-Hansen S, et al.
Mol Pharm
. 2023 May;
20(6):2951-2965.
PMID: 37146162
Therapeutic proteins can be challenging to develop due to their complexity and the requirement of an acceptable formulation to ensure patient safety and efficacy. To date, there is no universal...
8.
Bramham J, Golovanov A
Commun Chem
. 2023 Jan;
5(1):90.
PMID: 36697806
In situ illumination of liquid-state nuclear magnetic resonance (NMR) samples makes it possible for a wide range of light-dependent chemical and biological phenomena to be studied by the powerful analytical...
9.
Gorman A, Golovanov A
Eur J Pharm Biopharm
. 2022 Oct;
180:289-307.
PMID: 36272656
Lipopolysaccharide (LPS) is a cell-wall component of Gram-negative bacteria which contributes to bacterial toxicity. During processes such as cell division, shedding of outer membrane vesicles, or bacterial cell death, LPS...
10.
Svilenov H, Kopp K, Golovanov A, Winter G, Zalar M
J Pharm Sci
. 2022 Oct;
112(2):404-410.
PMID: 36257338
Surfactants are commonly used in biopharmaceutical formulations to stabilize proteins against aggregation. However, the choice of a suitable surfactant for a particular protein is decided mostly empirically, and their mechanism...