James H Thierer
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Explore the profile of James H Thierer including associated specialties, affiliations and a list of published articles.
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11
Citations
236
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Recent Articles
1.
Kelpsch D, Zhang L, Thierer J, Koren K, Kumar U, Lin Y, et al.
bioRxiv
. 2024 Nov;
PMID: 39605440
Lipoproteins are essential for lipid transport in all bilaterians. A single Apolipoprotein B (ApoB) molecule is the inseparable structural scaffold of each ApoB-containing lipoprotein (B-lps), which are responsible for transporting...
2.
Thierer J, Foresti O, Yadav P, Wilson M, Moll T, Shen M, et al.
Nat Commun
. 2024 Mar;
15(1):2572.
PMID: 38519494
No abstract available.
3.
Thierer J, Foresti O, Yadav P, Wilson M, Moll T, Shen M, et al.
Nat Commun
. 2024 Mar;
15(1):2095.
PMID: 38453914
Vertebrates transport hydrophobic triglycerides through the circulatory system by packaging them within amphipathic particles called Triglyceride-Rich Lipoproteins. Yet, it remains largely unknown how triglycerides are loaded onto these particles. Mutations...
4.
Jawahar J, McCumber A, Lickwar C, Amoroso C, Gomez de la Torre Canny S, Wong S, et al.
BMC Genomics
. 2022 Mar;
23(1):225.
PMID: 35317738
Background: The ability of animals and their microbiomes to adapt to starvation and then restore homeostasis after refeeding is fundamental to their continued survival and symbiosis. The intestine is the...
5.
A point mutation decouples the lipid transfer activities of microsomal triglyceride transfer protein
Wilson M, Rajan S, Danoff A, White R, Hensley M, Quinlivan V, et al.
PLoS Genet
. 2020 Aug;
16(8):e1008941.
PMID: 32760060
Apolipoprotein B-containing lipoproteins (B-lps) are essential for the transport of hydrophobic dietary and endogenous lipids through the circulation in vertebrates. Zebrafish embryos produce large numbers of B-lps in the yolk...
6.
Thierer J, Ekker S, Farber S
Nat Commun
. 2020 Jul;
11(1):3707.
PMID: 32694507
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
7.
Walsh M, Celestin O, Thierer J, Rajan S, Farber S, Hussain M
J Lipid Res
. 2020 Jan;
61(3):316-327.
PMID: 31888978
apoB exists as apoB100 and apoB48, which are mainly found in hepatic VLDLs and intestinal chylomicrons, respectively. Elevated plasma levels of apoB-containing lipoproteins (Blps) contribute to coronary artery disease, diabetes,...
8.
Thierer J, Ekker S, Farber S
Nat Commun
. 2019 Aug;
10(1):3426.
PMID: 31366908
Apolipoprotein-B (ApoB) is the structural component of atherogenic lipoproteins, lipid-rich particles that drive atherosclerosis by accumulating in the vascular wall. As atherosclerotic cardiovascular disease is the leading cause of death...
9.
Ju C, Van de Poel B, Cooper E, Thierer J, Gibbons T, Delwiche C, et al.
Nat Plants
. 2016 Jun;
1:14004.
PMID: 27246051
Land plants evolved more than 450 million years ago from a lineage of freshwater charophyte green algae(1). The extent to which plant signalling systems existed before the evolutionary transition to...
10.
Otis J, Zeituni E, Thierer J, Anderson J, Brown A, Boehm E, et al.
Dis Model Mech
. 2015 Jan;
8(3):295-309.
PMID: 25633982
Improved understanding of lipoproteins, particles that transport lipids throughout the circulation, is vital to developing new treatments for the dyslipidemias associated with metabolic syndrome. Apolipoproteins are a key component of...