Stephen C Ekker
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Explore the profile of Stephen C Ekker including associated specialties, affiliations and a list of published articles.
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157
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5211
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Recent Articles
1.
Ming Z, Liu F, Moran H, Lalonde R, Adams M, Restrepo N, et al.
bioRxiv
. 2024 Dec;
PMID: 39677658
Background: The ability to generate endogenous Cre recombinase drivers using CRISPR-Cas9 knock-in technology allows lineage tracing, cell type specific gene studies, and validation of inferred developmental trajectories from phenotypic and...
2.
Castillo S, Simone B, Clark K, Devaux P, Ekker S
Hum Gene Ther
. 2024 Aug;
35(19-20):798-813.
PMID: 39212664
DddA-derived cytosine base editors (DdCBEs) enable the targeted introduction of C•G-to-T•A conversions in mitochondrial DNA (mtDNA). DdCBEs work in pairs, with each arm composed of a transcription activator-like effector (TALE),...
3.
Castillo S, Simone B, Clark K, Devaux P, Ekker S
bioRxiv
. 2024 May;
PMID: 38798498
DddA-derived cytosine base editors (DdCBEs) enable the targeted introduction of C•G-to-T•A conversions in mitochondrial DNA (mtDNA). DdCBEs are often deployed as pairs, with each arm comprised of a transcription activator-like...
4.
Shams S, Olson S, Ekker M, Salmi A, Ekker S, Pierret C
Zebrafish
. 2024 Apr;
21(2):101-108.
PMID: 38621211
Microscopes are essential for research and education in science. Unlike computers and online learning tools, however, microscopes are not currently a fixed element in K-12 classrooms, due to steep cost,...
5.
6.
Kar B, Castillo S, Sabharwal A, Clark K, Ekker S
Int J Mol Sci
. 2023 Mar;
24(6).
PMID: 36982871
Mitochondria are critical organelles that form networks within our cells, generate energy dynamically, contribute to diverse cell and organ function, and produce a variety of critical signaling molecules, such as...
7.
Sabharwal A, Wishman M, Cervera R, Serres M, Anderson J, Holmberg S, et al.
Elife
. 2022 Nov;
11.
PMID: 36408801
The clinical and largely unpredictable heterogeneity of phenotypes in patients with mitochondrial disorders demonstrates the ongoing challenges in the understanding of this semi-autonomous organelle in biology and disease. Previously, we...
8.
Ding Y, Lang D, Yan J, Bu H, Li H, Jiao K, et al.
Elife
. 2022 Oct;
11.
PMID: 36255053
Previously we showed the generation of a protein trap library made with the gene-break transposon (GBT) in zebrafish () that could be used to facilitate novel functional genome annotation towards...
9.
Rapid Adaptation and Remote Delivery of Undergraduate Research Training during the COVID-19 Pandemic
Yowler J, Knier K, WareJoncas Z, Ehlers S, Ekker S, Reyes F, et al.
Sustainability
. 2022 Oct;
13(11).
PMID: 36185775
When COVID-19 caused worldwide cancellations of summer research immersion programs in 2020, Mayo Clinic rallied to create an alternate virtual experience called Summer Foundations in Research (SFIR). SFIR was designed...
10.
Cheng K, Burdine R, Dickinson M, Ekker S, Lin A, Lloyd K, et al.
Dis Model Mech
. 2022 Sep;
15(9).
PMID: 36125045
Model organism (MO) research provides a basic understanding of biology and disease due to the evolutionary conservation of the molecular and cellular language of life. MOs have been used to...