James H Steer
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Explore the profile of James H Steer including associated specialties, affiliations and a list of published articles.
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24
Citations
418
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Recent Articles
1.
Poh A, Love C, Chisanga D, Steer J, Baloyan D, Chopin M, et al.
Sci Adv
. 2022 Jun;
8(25):eabl7882.
PMID: 35731867
Although immunotherapy has revolutionized cancer treatment, many immunogenic tumors remain refractory to treatment. This can be largely attributed to an immunologically "cold" tumor microenvironment characterized by an accumulation of immunosuppressive...
2.
Murrey M, Steer J, Greenland E, Proudfoot J, Joyce D, Pixley F
J Cell Sci
. 2020 Feb;
133(5).
PMID: 32005697
Migratory macrophages play critical roles in tissue development, homeostasis and disease, so it is important to understand how their migration machinery is regulated. Whole-transcriptome sequencing revealed that CSF-1-stimulated differentiation of...
3.
Zhu X, Gao J, Landao-Bassonga E, Pavlos N, Qin A, Steer J, et al.
Biochem Pharmacol
. 2016 Feb;
104:118-30.
PMID: 26906912
Osteoclasts (OCs) play a pivotal role in a variety of lytic bone diseases including osteoporosis, arthritis, bone tumors, Paget's disease and the aseptic loosening of orthopedic implants. The primary focus...
4.
Dwyer A, Mouchemore K, Steer J, Sunderland A, Sampaio N, Greenland E, et al.
J Leukoc Biol
. 2016 Jan;
100(1):163-75.
PMID: 26747837
A major role of colony-stimulating factor-1 is to stimulate the differentiation of mononuclear phagocytic lineage cells into adherent, motile, mature macrophages. The colony-stimulating factor-1 receptor transduces colony-stimulating factor-1 signaling, and...
5.
Zhu X, Gao J, Ng P, Qin A, Steer J, Pavlos N, et al.
J Bone Miner Res
. 2015 Sep;
31(3):560-72.
PMID: 26363136
Aseptic loosening and periprosthetic infection leading to inflammatory osteolysis is a major complication associated with total joint arthroplasty (TJA). The liberation of bacterial products and/or implant-derived wear particles activates immune...
6.
Early induction of uncoupling protein-2 in pulmonary macrophages in hyperoxia-associated lung injury
Steer J, Mann T, Lo S, Inglis J, Yap H, Henry P, et al.
Inhal Toxicol
. 2013 Aug;
25(9):544-52.
PMID: 23905971
Context: High concentrations of inspired oxygen contribute to the pathogenesis of neonatal bronchopulmonary dysplasia and adult acute respiratory distress syndrome. Animal models of hyperoxia-associated lung injury (HALI) are characterized by...
7.
Ang E, Pavlos N, Chim S, Feng H, Scaife R, Steer J, et al.
J Cell Biochem
. 2011 Oct;
113(3):946-55.
PMID: 22034016
Pathological bone destruction (osteolysis) is a hallmark of many bone diseases including tumor metastasis to bone, locally osteolytic giant cell tumor (GCT) of bone, and Paget's disease. Paclitaxel is frequently...
8.
Lo S, Steer J, Joyce D
Cancer Lett
. 2011 Apr;
307(1):80-92.
PMID: 21482450
The abundance of macrophages is an independent negative prognostic factor in a range of cancer types, linked to the actions of macrophage products on vasculogenesis and cancer cell survival, motility...
9.
Lo S, Steer J, Joyce D
Arthritis Res Ther
. 2011 Feb;
13(1):R24.
PMID: 21324111
Introduction: Methotrexate (MTX) induces macrophage apoptosis in vitro, but there is not much evidence for increased synovial macrophage apoptosis in MTX-treated patients. Macrophage apoptosis is reported, however, during clinical response...
10.
Thien C, Dagger S, Steer J, Koentgen F, Jansen E, Scott C, et al.
J Biol Chem
. 2010 Feb;
285(14):10969-81.
PMID: 20133944
The ability of thymocytes to assess T cell receptor (TCR) signaling strength and initiate the appropriate downstream response is crucial for determining their fate. We have previously shown that a...