Nathan J Pavlos
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Explore the profile of Nathan J Pavlos including associated specialties, affiliations and a list of published articles.
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66
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2544
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Recent Articles
1.
King J, Chen K, Evans C, Norret M, Almasri R, Pavlos N, et al.
Chem Sci
. 2024 Sep;
PMID: 39246363
Antisense oligonucleotides (ASOs) are a well-established therapeutic modality based on RNA interference, but low cellular uptake, limited ability to direct ASO trafficking, and a range of intracellular barriers to successful...
2.
Dufrancais O, Verdys P, Plozza M, Metais A, Juzans M, Sanchez T, et al.
bioRxiv
. 2024 May;
PMID: 38798563
Cell-cell fusion is an evolutionarily conserved process that is essential for many functions, including fertilisation and the formation of placenta, muscle and osteoclasts, multinucleated cells that are unique in their...
3.
Kenny J, Mullin B, Tomlinson W, Robertson B, Yuan J, Chen W, et al.
Arthritis Res Ther
. 2023 Dec;
25(1):232.
PMID: 38041181
Objectives: Osteoarthritis (OA) is a joint disease with a heritable component. Genetic loci identified via genome-wide association studies (GWAS) account for an estimated 26.3% of the disease trait variance in...
4.
Mullin B, Zhu K, Brown S, Mullin S, Dudbridge F, Pavlos N, et al.
Genetics
. 2023 Aug;
225(2).
PMID: 37579195
There has been a growing interest in the role of the subchondral bone and its resident osteoclasts in the progression of osteoarthritis (OA). A recent genome-wide association study (GWAS) identified...
5.
Mullin B, Ribet A, Pavlos N
Curr Osteoporos Rep
. 2023 Jul;
21(5):493-502.
PMID: 37410317
Purpose Of Review: Recent advancements in "omics" technologies and bioinformatics have afforded researchers new tools to study bone biology in an unbiased and holistic way. The purpose of this review...
6.
Ng P, Ribet A, Guo Q, Mullin B, Tan J, Landao-Bassonga E, et al.
Nat Commun
. 2023 Feb;
14(1):906.
PMID: 36810735
Osteoclasts are giant bone-digesting cells that harbor specialized lysosome-related organelles termed secretory lysosomes (SLs). SLs store cathepsin K and serve as a membrane precursor to the ruffled border, the osteoclast's...
7.
Mullin B, Pavlos N, Brown S, Walsh J, McKellar R, Wilson S, et al.
J Endocr Soc
. 2022 Mar;
6(5):bvac025.
PMID: 35356007
Context: In the clinic it is important to differentiate primary hyperparathyroidism (PHPT) from the more benign, inherited disorder, familial hypocalciuric hypercalcemia (FHH). Since the conditions may sometimes overlap biochemically, identification...
8.
Rauner M, Foessl I, Formosa M, Kague E, Prijatelj V, Lopez N, et al.
Front Endocrinol (Lausanne)
. 2021 Dec;
12:731217.
PMID: 34938269
The availability of large human datasets for genome-wide association studies (GWAS) and the advancement of sequencing technologies have boosted the identification of genetic variants in complex and rare diseases in...
9.
Chen K, Liao S, Li Y, Jiang H, Liu Y, Wang C, et al.
Theranostics
. 2021 Nov;
11(20):9738-9751.
PMID: 34815781
Angiogenesis and osteogenesis are highly coupled processes which are indispensable to bone repair. However, the underlying mechanism(s) remain elusive. To bridge the gap in understanding the coupling process is crucial...
10.
Sultana M, Cluning C, Kwong W, Polain N, Pavlos N, Ratajczak T, et al.
PLoS One
. 2021 Nov;
16(11):e0259556.
PMID: 34735553
The LIM-domain containing protein Ajuba and the scaffold protein SQSTM1/p62 regulate signalling of NF-κB, a transcription factor involved in osteoclast differentiation and survival. The ubiquitin-associated domain of SQSTM1/p62 is frequently...