James F Tobin
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Explore the profile of James F Tobin including associated specialties, affiliations and a list of published articles.
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27
Citations
1136
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Recent Articles
1.
Wan Z, Chenail E, Li H, Ipek M, Xiang J, Suri V, et al.
ACS Med Chem Lett
. 2014 Jun;
4(1):118-23.
PMID: 24900572
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyzes the conversion of inactive glucocorticoid cortisone to its active form, cortisol. The glucocorticoid receptor (GR) signaling pathway has been linked to the pathophysiology of...
2.
Cao J, Perez S, Goodwin B, Lin Q, Peng H, Qadri A, et al.
Am J Physiol Endocrinol Metab
. 2014 Apr;
306(10):E1176-87.
PMID: 24714397
Glycerol-3-phosphate acyltransferases (GPATs) catalyze the first step in the synthesis of glycerolipids and glycerophospholipids. Microsomal GPAT, the major GPAT activity, is encoded by at least two closely related genes, GPAT3...
3.
Ivanciu L, Toso R, Margaritis P, Pavani G, Kim H, Schlachterman A, et al.
Nat Biotechnol
. 2011 Oct;
29(11):1028-33.
PMID: 22020385
Effective therapies are needed to control excessive bleeding in a range of clinical conditions. We improve hemostasis in vivo using a conformationally pliant variant of coagulation factor Xa (FXa(I16L)) rendered...
4.
Cao J, Zhou Y, Peng H, Huang X, Stahler S, Suri V, et al.
J Biol Chem
. 2011 Oct;
286(48):41838-41851.
PMID: 21990351
Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) is one of two known DGAT enzymes that catalyze the final step in triglyceride synthesis. Findings from genetically modified mice as well as pharmacological studies suggest...
5.
Shan D, Li J, Wu L, Li D, Hurov J, Tobin J, et al.
J Lipid Res
. 2010 Feb;
51(7):1971-81.
PMID: 20181984
Acyl-CoA:glycerol-3-phosphate acyltransferase (GPAT) catalyzes the first step during de novo synthesis of glycerolipids. Mammals have at least four GPAT isoforms. Here we report the further characterization of the two recently...
6.
Wan Z, Chenail E, Xiang J, Li H, Ipek M, Bard J, et al.
J Med Chem
. 2009 Aug;
52(17):5449-61.
PMID: 19673466
Cortisol and the glucocorticoid receptor signaling pathway have been implicated in the development of diabetes and obesity. The reduction of cortisone to cortisol is catalyzed by 11beta-hydroxysteroid dehydrogenase type I...
7.
Tremblay F, Revett T, Huard C, Zhang Y, Tobin J, Martinez R, et al.
J Biol Chem
. 2009 Jan;
284(12):8136-47.
PMID: 19141617
Adipocyte-secreted proteins play important roles in metabolic regulation through autocrine, paracrine, and endocrine mechanisms. Using transcriptional profiling, we identified coiled-coil domain containing 80 (Ccdc80; also known as DRO1 and URB)...
8.
Zhang Y, Zhong X, Gjoka Z, Li Y, Stochaj W, Stahl M, et al.
Arch Biochem Biophys
. 2009 Jan;
483(1):45-54.
PMID: 19121282
Tissue specific amplification of glucocorticoid action through NADPH-dependent reduction of inactive glucocorticoid precursors by 11beta-hydroxysteroid dehydrogenase (11beta-HSD1) contributes to the development of visceral obesity, insulin resistance and Type 2 Diabetes....
9.
Artis D, Lin J, Zhang C, Wang W, Mehra U, Perreault M, et al.
Proc Natl Acad Sci U S A
. 2009 Jan;
106(1):262-7.
PMID: 19116277
In a search for more effective anti-diabetic treatment, we used a process coupling low-affinity biochemical screening with high-throughput co-crystallography in the design of a series of compounds that selectively modulate...
10.
Perreault M, Erbe D, Tobin J
PPAR Res
. 2008 Nov;
2008:125387.
PMID: 18989368
The prevalence of obesity in the USA and worldwide has reached epidemic proportions during the last two decades. Drugs currently available for the treatment of obesity provide no more than...