James E Posey
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Explore the profile of James E Posey including associated specialties, affiliations and a list of published articles.
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42
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1517
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Recent Articles
1.
Springer Y, Tompkins M, Newell K, Jones M, Burns S, Chandler B, et al.
J Infect Dis
. 2024 May;
231(1):94-102.
PMID: 38794931
Background: Understanding the etiology of recurrent tuberculosis (rTB) is important for effective tuberculosis control. Prior to the advent of whole genome sequencing (WGS), attributing rTB to relapse or reinfection using...
2.
Carter J, Walker T, Walker A, Whitfield M, Morlock G, Lynch C, et al.
JAC Antimicrob Resist
. 2024 Mar;
6(2):dlae037.
PMID: 38500518
Background: Pyrazinamide is one of four first-line antibiotics used to treat tuberculosis; however, antibiotic susceptibility testing for pyrazinamide is challenging. Resistance to pyrazinamide is primarily driven by genetic variation in...
3.
Pang A, Green K, Chandrika N, Garzan A, Punetha A, Holbrook S, et al.
Eur J Med Chem
. 2022 Aug;
242:114698.
PMID: 36037791
A clinically significant mechanism of tuberculosis resistance to the aminoglycoside kanamycin (KAN) is its acetylation catalyzed by upregulated Mycobacterium tuberculosis (Mtb) acetyltransferase Eis. In search for inhibitors of Eis, we...
4.
Raz K, Talarico S, Althomsons S, Kammerer J, Cowan L, Haddad M, et al.
Tuberculosis (Edinb)
. 2022 Aug;
136:102232.
PMID: 35969928
Objective: This study describes characteristics of large tuberculosis (TB) outbreaks in the United States detected using novel molecular surveillance methods during 2014-2016 and followed for 2 years through 2018. Methods:...
5.
Punetha A, Green K, Garzan A, Chandrika N, Willby M, Pang A, et al.
RSC Med Chem
. 2021 Nov;
12(11):1894-1909.
PMID: 34825186
Tuberculosis (TB), caused by (), is a deadly bacterial disease. Drug-resistant strains of make eradication of TB a daunting task. Overexpression of the enhanced intracellular survival (Eis) protein by confers...
6.
Willby M, Chopra P, Lemmer D, Klein K, Dalton T, Engelthaler D, et al.
Antimicrob Agents Chemother
. 2020 Oct;
65(1).
PMID: 33106264
Fluoroquinolones (FQ) are crucial components of multidrug-resistant tuberculosis (MDR TB) treatment. Differing levels of resistance are associated with specific mutations within the uinolone-esistance-etermining egion (QRDR) of We sequenced the QRDR...
7.
Punetha A, Ngo H, Holbrook S, Green K, Willby M, Bonnett S, et al.
ACS Chem Biol
. 2020 May;
15(6):1581-1594.
PMID: 32421305
The enhanced intracellular survival (Eis) protein of () is a versatile acetyltransferase that multiacetylates aminoglycoside antibiotics abolishing their binding to the bacterial ribosome. When overexpressed as a result of promoter...
8.
Click E, Kurbatova E, Alexander H, Dalton T, Chen M, Posey J, et al.
J Infect Dis
. 2020 Feb;
221(12):2072-2082.
PMID: 32002554
Background: Mutations in the genes inhA, katG, and rpoB confer resistance to anti-tuberculosis (TB) drugs isoniazid and rifampin. We questioned whether specific mutations in these genes were associated with different...
9.
Armstrong G, MacCannell D, Taylor J, Carleton H, Neuhaus E, Bradbury R, et al.
N Engl J Med
. 2019 Dec;
381(26):2569-2580.
PMID: 31881145
Rapid advances in DNA sequencing technology ("next-generation sequencing") have inspired optimism about the potential of human genomics for "precision medicine." Meanwhile, pathogen genomics is already delivering "precision public health" through...
10.
Sable S, Posey J, Scriba T
Clin Microbiol Rev
. 2019 Nov;
33(1).
PMID: 31666281
Tuberculosis (TB) is the leading killer among all infectious diseases worldwide despite extensive use of the bacille Calmette-Guérin (BCG) vaccine. A safer and more effective vaccine than BCG is urgently...