James Dowden
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Explore the profile of James Dowden including associated specialties, affiliations and a list of published articles.
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19
Citations
269
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Recent Articles
1.
Gunnell E, Al-Noori A, Muhsen U, Davies C, Dowden J, Dreveny I
Biochem J
. 2020 Feb;
477(4):787-800.
PMID: 32011657
Attenuating the function of protein arginine methyltransferases (PRMTs) is an objective for the investigation and treatment of several diseases including cardiovascular disease and cancer. Bisubstrate inhibitors that simultaneously target binding...
2.
Douglas T, Pordea A, Dowden J
Org Lett
. 2017 Nov;
19(23):6396-6399.
PMID: 29144763
The iron(III)-catalyzed synthesis of indolizines from commercially available alkyne, pyridine, and diazo precursors is reported. This mild, expedient method is tolerant of various solvents and proceeds with as little as...
3.
Day J, McKeever-Abbas B, Dowden J
Angew Chem Int Ed Engl
. 2016 Apr;
55(19):5809-13.
PMID: 27059910
Commercially available iron(III) and copper(I) complexes catalyzed multicomponent cycloaddition reactions between diazo compounds, pyridines, and electrophilic alkenes to give alkaloid-inspired tetrahydroindolizidines in high yield with high diastereoselectivity. Hitherto, the catalytic...
4.
Hanson-Heine M, Wriglesworth A, Uroos M, Calladine J, Murphy T, Hamilton M, et al.
J Chem Phys
. 2015 Apr;
142(15):154119.
PMID: 25903878
In contrast to the ground state, the calculation of the infrared (IR) spectroscopy of molecular singlet excited states represents a substantial challenge. Here, we use the structural IR fingerprint of...
5.
Day J, Uroos M, Castledine R, Lewis W, McKeever-Abbas B, Dowden J
Org Biomol Chem
. 2013 Aug;
11(38):6502-9.
PMID: 23989496
Cycloaddition reactions between pyridinium ylides and 3-alkenyl oxindoles that proceed in high yield and with very good regio- and diastereoselectivity are reported. The resulting cycloadducts have the same stereochemistry of...
6.
You B, Hamer K, Lewis W, Dowden J
Chem Commun (Camb)
. 2012 Nov;
49(8):795-7.
PMID: 23192361
A silicon mediated intramolecular 1,4-conjugate addition of a homoallylic carbon nucleophile leading to cyclopropanation is reported. Specifically, treatment of 6-trimethylsilyl-5,6-dihydroazocinones with fluoride gives 4-azabicyclo(5.1.0)octenones, presenting an unusual extension to the...
7.
Dowden J, Pike R, Parry R, Hong W, Muhsen U, Ward S
Org Biomol Chem
. 2011 Sep;
9(22):7814-21.
PMID: 21952734
Protein arginine N-methyltransferases (PRMTs) selectively replace N-H for N-CH(3) at substrate protein guanidines, a post-translational modification important for a range of biological processes, such as epigenetic regulation, signal transduction and...
8.
Dowden J, Hong W, Parry R, Pike R, Ward S
Bioorg Med Chem Lett
. 2010 Mar;
20(7):2103-5.
PMID: 20219369
Prototype inhibitors of protein arginine methyltransferases (PRMTs) have been constructed by attaching guanidine functionality via a variable linker to non-reactive amine analogues of the cellular co-factor (S)-adenosyl methionine (AdoMet). Potent...
9.
Dammermann W, Zhang B, Nebel M, Cordiglieri C, Odoardi F, Kirchberger T, et al.
Proc Natl Acad Sci U S A
. 2009 Jun;
106(26):10678-83.
PMID: 19541638
The nucleotide NAADP was recently discovered as a second messenger involved in the initiation and propagation of Ca(2+) signaling in lymphoma T cells, but its impact on primary T cell...
10.
Parkesh R, Lewis A, Aley P, Arredouani A, Rossi S, Tavares R, et al.
Cell Calcium
. 2007 Oct;
43(6):531-8.
PMID: 17935780
NAADP (nicotinic acid adenine dinucleotide phosphate) is a recently discovered second messenger, and as such, we have much yet to learn about its functions in health and disease. A bottleneck...