James Dowden
Overview
Explore the profile of James Dowden including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
19
Citations
269
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Foster S, Pearce A, Blake A, Welham M, Dowden J
Chem Commun (Camb)
. 2007 Jun;
(24):2512-4.
PMID: 17563813
A novel octavalent, resorcin[4]arene derived, cross-linker designed to overcome some of the limitations of commercially available reagents is significantly more efficient for covalent stabilisation of protein-protein interactions.
12.
Parkesh R, Vasudevan S, Berry A, Galione A, Dowden J, Churchill G
Org Biomol Chem
. 2007 Jan;
5(3):441-3.
PMID: 17252124
A chemo-enzymatic synthesis of novel caged NAADP+ without the formation of multiple cage compounds has been achieved. The biological activity of the caged NAADP+ was demonstrated by its fast uncaging...
13.
Anderson C, Bartlett S, Gansner J, Wilson D, He L, Gitlin J, et al.
Mol Biosyst
. 2007 Jan;
3(1):51-9.
PMID: 17216056
As a result of a chemical genetic screen for modulators of metalloprotease activity, we report that 2-mercaptopyridine-N-oxide induces a conspicuous undulating notochord defect in zebrafish embryos, a phenocopy of the...
14.
Dowden J, Berridge G, Moreau C, Yamasaki M, Churchill G, Potter B, et al.
Chem Biol
. 2006 Jun;
13(6):659-65.
PMID: 16793523
Nicotinic acid adenine dinucleotide phosphate (NAADP, 1) is the most potent intracellular Ca2+ mobilizing agent in important mammalian cells and tissues, yet the identity of the NAADP receptor is elusive....
15.
Yiakouvaki A, Savovic J, Al-Qenaei A, Dowden J, Pourzand C
J Invest Dermatol
. 2006 May;
126(10):2287-95.
PMID: 16710308
Exposure of human skin cells to solar UVA radiation leads to an immediate dose-dependent increase of labile iron that subsequently promotes oxidative damage and necrotic cell death. Strong iron chelators...
16.
Dowden J, Brown R, Moreau C, Galione A, Potter B
Nucleosides Nucleotides Nucleic Acids
. 2005 Oct;
24(5-7):513-8.
PMID: 16247981
The first total chemical synthesis of nicotinamide adenine dinucleotide phosphate (beta-NADP, 2) as a single isomer was achieved. This was subsequently converted into the important second messenger nicotinic acid adenine...
17.
Dowden J, Moreau C, Brown R, Berridge G, Galione A, Potter B
Angew Chem Int Ed Engl
. 2004 Sep;
43(35):4637-40.
PMID: 15352191
No abstract available.
18.
Ward S, Sotsios Y, Dowden J, Bruce I, Finan P
Chem Biol
. 2003 Apr;
10(3):207-13.
PMID: 12670534
At least one Holy Grail for many academic researchers and pharmaceutical research divisions alike has been to identify therapeutically useful selective PI3K inhibitors. There are several different but closely related...
19.
Yang J, Dowden J, Tatibouet A, Hatanaka Y, Holman G
Biochem J
. 2002 Jul;
367(Pt 2):533-9.
PMID: 12119043
The GLUT5 transporter catalyses the specific uptake of D-fructose and can accept this hexose in its furanose and pyranose ring forms. The transporter does not accept fructose epimers and has...