James D Manton
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Explore the profile of James D Manton including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
345
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Recent Articles
1.
Watson J, Kruger L, Ben-Sasson A, Bittleston A, Shahbazi M, Planelles-Herrero V, et al.
Cell
. 2023 Sep;
186(21):4710-4727.e35.
PMID: 37774705
Polarized cells rely on a polarized cytoskeleton to function. Yet, how cortical polarity cues induce cytoskeleton polarization remains elusive. Here, we capitalized on recently established designed 2D protein arrays to...
2.
Manton J
Philos Trans A Math Phys Eng Sci
. 2022 Feb;
380(2220):20210109.
PMID: 35152757
Structured illumination microscopy (SIM) provides images of fluorescent objects at an enhanced resolution greater than that of conventional epifluorescence wide-field microscopy. Initially demonstrated in 1999 to enhance the lateral resolution...
3.
Chang B, Manton J, Sapoznik E, Pohlkamp T, Terrones T, Welf E, et al.
Nat Methods
. 2021 Jun;
18(7):829-834.
PMID: 34183831
We introduce a cost-effective and easily implementable scan unit that converts any camera-based microscope with optical sectioning capability into a multi-angle projection imaging system. Projection imaging reduces data overhead and...
4.
Scherer K, Manton J, Soh T, Mascheroni L, Connor V, Crump C, et al.
J Biol Chem
. 2020 Dec;
296:100236.
PMID: 33380421
Herpesviruses are large and complex viruses that have a long history of coevolution with their host species. One important factor in the virus-host interaction is the alteration of intracellular morphology...
5.
Mascheroni L, Scherer K, Manton J, Ward E, Dibben O, Kaminski C
Biomed Opt Express
. 2020 Oct;
11(9):5032-5044.
PMID: 33014598
Expansion microscopy is a sample preparation technique that enables the optical imaging of biological specimens at super-resolution owing to their physical magnification, which is achieved through water-absorbing polymers. The technique...
6.
Chen B, Chakraborty T, Daetwyler S, Manton J, Dean K, Fiolka R
Biomed Opt Express
. 2020 Oct;
11(7):3830-3842.
PMID: 33014569
We present a beam splitter mask that can be easily added to a multiphoton raster scanning microscope to extend the depth of focus five-fold at a small loss in lateral...
7.
Lautenschlager J, Wagner-Valladolid S, Stephens A, Fernandez-Villegas A, Hockings C, Mishra A, et al.
J Biol Chem
. 2020 May;
295(30):10138-10152.
PMID: 32385113
Mitochondrial dysfunction has long been implicated in the neurodegenerative disorder Parkinson's disease (PD); however, it is unclear how mitochondrial impairment and α-synuclein pathology are coupled. Using specific mitochondrial inhibitors, EM...
8.
Manton J, Strohl F, Fiolka R, Kaminski C, Rees E
Biomed Opt Express
. 2020 Apr;
11(4):2098-2108.
PMID: 32341869
Wide-field fluorescence microscopy, while much faster than confocal microscopy, suffers from a lack of optical sectioning and poor axial resolution. 3D structured illumination microscopy (SIM) has been demonstrated to provide...
9.
Bates A, Manton J, Jagannathan S, Costa M, Schlegel P, Rohlfing T, et al.
Elife
. 2020 Apr;
9.
PMID: 32286229
To analyse neuron data at scale, neuroscientists expend substantial effort reading documentation, installing dependencies and moving between analysis and visualisation environments. To facilitate this, we have developed a suite of...
10.
Kay R, Williams T, Manton J, Traynor D, Paschke P
Int J Dev Biol
. 2019 Dec;
63(8-9-10):473-483.
PMID: 31840785
Macropinocytosis is used by a variety of amoebae for feeding on liquid medium. The amoebae project cups and ruffles from their plasma membrane, driven by actin polymerization, and eventually fuse...