James C Paulson
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Explore the profile of James C Paulson including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Lei R, Liang W, Ouyang W, Hernandez Garcia A, Kikuchi C, Wang S, et al.
Nat Commun
. 2024 Jun;
15(1):5175.
PMID: 38890325
The receptor-binding site of influenza A virus hemagglutinin partially overlaps with major antigenic sites and constantly evolves. In this study, we observe that mutations G186D and D190N in the hemagglutinin...
12.
Schiffner T, Phung I, Ray R, Irimia A, Tian M, Swanson O, et al.
Nat Immunol
. 2024 Jun;
25(7):1307.
PMID: 38877179
No abstract available.
13.
Le Sage V, Rockey N, French A, McBride R, McCarthy K, Rigatti L, et al.
Nat Commun
. 2024 Jun;
15(1):5025.
PMID: 38871701
Influenza A viruses in swine have considerable genetic diversity and continue to pose a pandemic threat to humans due to a potential lack of population level immunity. Here we describe...
14.
Schiffner T, Phung I, Ray R, Irimia A, Tian M, Swanson O, et al.
Nat Immunol
. 2024 May;
25(6):1073-1082.
PMID: 38816615
A key barrier to the development of vaccines that induce broadly neutralizing antibodies (bnAbs) against human immunodeficiency virus (HIV) and other viruses of high antigenic diversity is the design of...
15.
Cottrell C, Hu X, Lee J, Skog P, Luo S, Flynn C, et al.
Sci Transl Med
. 2024 May;
16(748):eadn0223.
PMID: 38753806
A protective HIV vaccine will likely need to induce broadly neutralizing antibodies (bnAbs). Vaccination with the germline-targeting immunogen eOD-GT8 60mer adjuvanted with AS01 was found to induce VRC01-class bnAb precursors...
16.
Xie Z, Lin Y, Steichen J, Ozorowski G, Kratochvil S, Ray R, et al.
Science
. 2024 May;
384(6697):eadk0582.
PMID: 38753770
Germline-targeting (GT) HIV vaccine strategies are predicated on deriving broadly neutralizing antibodies (bnAbs) through multiple boost immunogens. However, as the recruitment of memory B cells (MBCs) to germinal centers (GCs)...
17.
Steichen J, Phung I, Salcedo E, Ozorowski G, Willis J, Baboo S, et al.
Science
. 2024 May;
384(6697):eadj8321.
PMID: 38753769
Germline-targeting immunogens hold promise for initiating the induction of broadly neutralizing antibodies (bnAbs) to HIV and other pathogens. However, antibody-antigen recognition is typically dominated by heavy chain complementarity determining region...
18.
El-Shesheny R, Franks J, Kandeil A, Badra R, Turner J, Seiler P, et al.
Nat Commun
. 2024 Apr;
15(1):3449.
PMID: 38664384
In 2017, a novel influenza A virus (IAV) was isolated from an Egyptian fruit bat. In contrast to other bat influenza viruses, the virus was related to avian A(H9N2) viruses...
19.
Barshow S, Islam M, Commins S, Macauley M, Paulson J, Kulis M
J Allergy Clin Immunol
. 2024 Apr;
154(2):492-497.e1.
PMID: 38593870
Background: Sialic acid-binding immunoglobulin-like lectin-3 (Siglec-3 [CD33]) is a major Siglec expressed on human mast cells and basophils; engagement of CD33 leads to inhibition of cellular signaling via immunoreceptor tyrosine-based...
20.
Atxabal U, Nycholat C, Propster J, Fernandez A, Oyenarte I, Pia Lenza M, et al.
ACS Chem Biol
. 2024 Feb;
19(2):483-496.
PMID: 38321945
Human sialic-acid-binding immunoglobulin-like lectin-9 (Siglec-9) is a glycoimmune checkpoint receptor expressed on several immune cells. Binding of Siglec-9 to sialic acid containing glycans (sialoglycans) is well documented to modulate its...