Corwin M Nycholat
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Explore the profile of Corwin M Nycholat including associated specialties, affiliations and a list of published articles.
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38
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1465
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Recent Articles
1.
Huang K, Bashian E, Zong G, Nycholat C, McBride R, Gomozkova M, et al.
JACS Au
. 2024 Aug;
4(8):2966-2978.
PMID: 39211606
Sulfated -glycans are present in many glycoproteins, which are implicated in playing important roles in biological recognition processes. Here, we report the systematic chemoenzymatic synthesis of a library of sulfated...
2.
Thompson A, Wu N, Canales A, Kikuchi C, Zhu X, de Toro B, et al.
Cell Host Microbe
. 2024 Feb;
32(2):261-275.e4.
PMID: 38307019
Hemagglutinins (HAs) from human influenza viruses descend from avian progenitors that bind α2-3-linked sialosides and must adapt to glycans with α2-6-linked sialic acids on human airway cells to transmit within...
3.
Canales A, Sastre J, Orduna J, Spruit C, Perez-Castells J, Dominguez G, et al.
JACS Au
. 2023 Apr;
3(3):868-878.
PMID: 37006776
Influenza virus infection remains a threat to human health since viral hemagglutinins are constantly drifting, escaping infection and vaccine-induced antibody responses. Viral hemagglutinins from different viruses display variability in glycan...
4.
Duan S, Arlian B, Nycholat C, Wei Y, Tateno H, Smith S, et al.
J Immunol
. 2021 Apr;
206(10):2290-2300.
PMID: 33911007
Siglec-8 is an inhibitory receptor expressed on eosinophils and mast cells. In this study, we took advantage of a novel Siglec-8 transgenic mouse model to assess the impact of modulating...
5.
Bull C, Nason R, Sun L, Van Coillie J, Sorensen D, Moons S, et al.
Proc Natl Acad Sci U S A
. 2021 Apr;
118(17).
PMID: 33893239
Siglecs are a family of sialic acid-binding receptors expressed by cells of the immune system and a few other cell types capable of modulating immune cell functions upon recognition of...
6.
Wu N, Otwinowski J, Thompson A, Nycholat C, Nourmohammad A, Wilson I
Nat Commun
. 2020 Mar;
11(1):1233.
PMID: 32144244
Antigenic drift of influenza virus hemagglutinin (HA) is enabled by facile evolvability. However, HA antigenic site B, which has become immunodominant in recent human H3N2 influenza viruses, is also evolutionarily...
7.
Nycholat C, Duan S, Knuplez E, Worth C, Elich M, Yao A, et al.
J Am Chem Soc
. 2019 Aug;
141(36):14032-14037.
PMID: 31460762
The Siglec family of cell surface receptors have emerged as attractive targets for cell-directed therapies due to their restricted expression on immune cells, endocytic properties, and ability to modulate receptor...
8.
Wu N, Lv H, Thompson A, Wu D, Ng W, Kadam R, et al.
Cell Host Microbe
. 2019 Jun;
25(6):836-844.e5.
PMID: 31151913
Egg-based seasonal influenza vaccines are the major preventive countermeasure against influenza virus. However, their effectiveness can be compromised when antigenic changes arise from egg-adaptive mutations on influenza hemagglutinin (HA). The...
9.
Bednar K, Nycholat C, Rao T, Paulson J, Fung-Leung W, Macauley M
ACS Chem Biol
. 2019 Mar;
14(4):644-654.
PMID: 30835424
Rheumatoid arthritis (RA) is an autoimmune disease that primarily affects the synovial joints and can lead to bone erosion and cartilage damage. One hallmark of RA is anticitrullinated protein autoantibodies...
10.
Duan S, Koziol-White C, Jester Jr W, Smith S, Nycholat C, Macauley M, et al.
J Clin Invest
. 2019 Jan;
129(3):1387-1401.
PMID: 30645205
Allergen immunotherapy for patients with allergies begins with weekly escalating doses of allergen under medical supervision to monitor and treat IgE mast cell-mediated anaphylaxis. There is currently no treatment to...