James C Mulloy
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Explore the profile of James C Mulloy including associated specialties, affiliations and a list of published articles.
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Articles
91
Citations
6106
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Recent Articles
1.
Lin S, Kotliar M, Vallabh S, Ptasinska A, Assi S, Wunderlich M, et al.
Blood Adv
. 2024 Dec;
9(4):856-861.
PMID: 39705535
No abstract available.
2.
Chen Z, Zeng C, Yang L, Che Y, Chen M, Sau L, et al.
Cell
. 2024 Dec;
188(2):331-351.e30.
PMID: 39694037
Long-term durable remission in patients with B cell malignancies following chimeric antigen receptor (CAR)-T cell immunotherapy remains unsatisfactory, often due to antigen escape. Malignant B cell transformation and oncogenic growth...
3.
Li Y, Xue M, Deng X, Dong L, Truong Nguyen L, Ren L, et al.
Cell Stem Cell
. 2023 Aug;
30(8):1072-1090.e10.
PMID: 37541212
TET2 is recurrently mutated in acute myeloid leukemia (AML) and its deficiency promotes leukemogenesis (driven by aggressive oncogenic mutations) and enhances leukemia stem cell (LSC) self-renewal. However, the underlying cellular/molecular...
4.
Bouffi C, Wikenheiser-Brokamp K, Chaturvedi P, Sundaram N, Goddard G, Wunderlich M, et al.
Nat Biotechnol
. 2023 Jan;
41(6):824-831.
PMID: 36702898
Human intestinal organoids (HIOs) derived from pluripotent stem cells provide a valuable model for investigating human intestinal organogenesis and physiology, but they lack the immune components required to fully recapitulate...
5.
Han L, Dong L, Leung K, Zhao Z, Li Y, Gao L, et al.
Cell Stem Cell
. 2023 Jan;
30(1):52-68.e13.
PMID: 36608679
N-methyladenosine (mA), the most prevalent internal modification in mammalian mRNAs, is involved in many pathological processes. METTL16 is a recently identified mA methyltransferase. However, its role in leukemia has yet...
6.
Liu X, Sato N, Yabushita T, Li J, Jia Y, Tamura M, et al.
EMBO Mol Med
. 2022 Dec;
15(1):e15631.
PMID: 36453131
Inosine monophosphate dehydrogenase (IMPDH) is a rate-limiting enzyme in de novo guanine nucleotide synthesis pathway. Although IMPDH inhibitors are widely used as effective immunosuppressants, their antitumor effects have not been...
7.
Weng H, Huang F, Yu Z, Chen Z, Prince E, Kang Y, et al.
Cancer Cell
. 2022 Oct;
40(12):1566-1582.e10.
PMID: 36306790
N-Methyladenosine (mA) modification and its modulators play critical roles and show promise as therapeutic targets in human cancers, including acute myeloid leukemia (AML). IGF2BP2 was recently reported as an mA...
8.
Tirtakusuma R, Szoltysek K, Milne P, Grinev V, Ptasinska A, Chin P, et al.
Blood
. 2022 Jul;
140(17):1875-1890.
PMID: 35839448
The fusion gene MLL/AF4 defines a high-risk subtype of pro-B acute lymphoblastic leukemia. Relapse can be associated with a lineage switch from acute lymphoblastic to acute myeloid leukemia, resulting in...
9.
Barreyro L, Sampson A, Ishikawa C, Hueneman K, Choi K, Pujato M, et al.
Sci Transl Med
. 2022 Mar;
14(635):eabb7695.
PMID: 35263148
Dysregulation of innate immune signaling pathways is implicated in various hematologic malignancies. However, these pathways have not been systematically examined in acute myeloid leukemia (AML). We report that AML hematopoietic...
10.
Zhao H, Lu J, Yan T, Han F, Sun J, Yin X, et al.
Cell Rep
. 2022 Jan;
38(4):110253.
PMID: 35081358
Acute myeloid leukemia (AML) is a genetically heterogeneous and frequently fatal malignancy. The ten-eleven translocation (TET)-mediated DNA demethylation is known to be critically associated with AML pathogenesis. Through chemical compound...