James Birch
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Explore the profile of James Birch including associated specialties, affiliations and a list of published articles.
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22
Citations
233
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Recent Articles
1.
Birch J, Kwan T, Judge P, Axford D, Aller P, Butryn A, et al.
J Appl Crystallogr
. 2023 Oct;
56(Pt 5):1361-1370.
PMID: 37791355
Serial crystallography has emerged as an important tool for structural studies of integral membrane proteins. The ability to collect data from micrometre-sized weakly diffracting crystals at room temperature with minimal...
2.
Hay A, Birch J, Ellis S, Burns D, Mansour S, Khakoo S, et al.
Vet Immunol Immunopathol
. 2023 Aug;
263:110646.
PMID: 37634416
Cattle, sheep, and goats are the only species outside primates known to have an expanded and diversified family of killer immunoglobulin-like receptors (KIR). Primate KIR are expressed on the surface...
3.
High-Throughput Production and Optimization of Membrane Proteins After Expression in Mammalian Cells
Gamage N, Cheruvara H, Harrison P, Birch J, Hitchman C, Olejnik M, et al.
Methods Mol Biol
. 2023 Apr;
2652:79-118.
PMID: 37093471
High-quality protein samples are an essential requirement of any structural biology experiment. However, producing high-quality protein samples, especially for membrane proteins, is iterative and time-consuming. Membrane protein structural biology remains...
4.
Axford D, Judge P, Bada Juarez J, Kwan T, Birch J, Vinals J, et al.
Acta Crystallogr D Struct Biol
. 2022 Jan;
78(Pt 1):52-58.
PMID: 34981761
Room-temperature diffraction methods are highly desirable for dynamic studies of biological macromolecules, since they allow high-resolution structural data to be collected as proteins undergo conformational changes. For crystals grown in...
5.
Birch J, Quigley A
Emerg Top Life Sci
. 2021 Oct;
5(5):655-663.
PMID: 34623416
Membrane proteins, found at the junctions between the outside world and the inner workings of the cell, play important roles in human disease and are used as biosensors. More than...
6.
Krasnoselska G, Dumoux M, Gamage N, Cheruvara H, Birch J, Quigley A, et al.
Methods Mol Biol
. 2021 May;
2305:105-128.
PMID: 33950386
Cancers, neurodegenerative and infectious diseases remain some of the leading causes of deaths worldwide. The structure-guided drug design is essential to advance drug development for these important diseases. One of...
7.
Bada Juarez J, Judge P, Adam S, Axford D, Vinals J, Birch J, et al.
Nat Commun
. 2021 Jan;
12(1):629.
PMID: 33504778
Many transmembrane receptors have a desensitized state, in which they are unable to respond to external stimuli. The family of microbial rhodopsin proteins includes one such group of receptors, whose...
8.
Birch J, Cheruvara H, Gamage N, Harrison P, Lithgo R, Quigley A
Biology (Basel)
. 2020 Nov;
9(11).
PMID: 33207666
Membrane proteins are essential components of many biochemical processes and are important pharmaceutical targets. Membrane protein structural biology provides the molecular rationale for these biochemical process as well as being...
9.
Gibson M, Allan A, Sanderson N, Birch J, Gubbins S, Ellis S, et al.
J Immunol
. 2020 Mar;
204(9):2455-2463.
PMID: 32213565
Cattle possess the most diverse repertoire of NK cell receptor genes among all mammals studied to date. Killer cell receptor genes encoded within the NK complex and killer cell Ig-like...
10.
Birch J, Axford D, Foadi J, Meyer A, Eckhardt A, Thielmann Y, et al.
Methods
. 2018 May;
147:150-162.
PMID: 29778646
Integral membrane proteins are among the most fascinating and important biomolecules as they play a vital role in many biological functions. Knowledge of their atomic structures is fundamental to the...