Isabel Moraes
Overview
Explore the profile of Isabel Moraes including associated specialties, affiliations and a list of published articles.
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Articles
34
Citations
672
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Recent Articles
1.
El Omari K, Duman R, Mykhaylyk V, Orr C, Latimer-Smith M, Winter G, et al.
Commun Chem
. 2023 Oct;
6(1):219.
PMID: 37828292
Despite recent advances in cryo-electron microscopy and artificial intelligence-based model predictions, a significant fraction of structure determinations by macromolecular crystallography still requires experimental phasing, usually by means of single-wavelength anomalous...
2.
Birch J, Kwan T, Judge P, Axford D, Aller P, Butryn A, et al.
J Appl Crystallogr
. 2023 Oct;
56(Pt 5):1361-1370.
PMID: 37791355
Serial crystallography has emerged as an important tool for structural studies of integral membrane proteins. The ability to collect data from micrometre-sized weakly diffracting crystals at room temperature with minimal...
3.
Kwan T, Danson A, Draper P, Reardon P, Moraes I
J Vis Exp
. 2023 Mar;
(193).
PMID: 36939230
Understanding the structure-function relationships of macromolecules, such as proteins, at the molecular level is vital for biomedicine and modern drug discovery. To date, X-ray crystallography remains the most successful method...
4.
Jones A, Moraes I, Quaglia M
Front Mol Biosci
. 2023 Feb;
10:1125791.
PMID: 36733436
No abstract available.
5.
Kwan T, Kolek S, Danson A, Reis R, Camacho I, Shaw Stewart P, et al.
Front Mol Biosci
. 2022 Jun;
9:890862.
PMID: 35651816
Structure-function relationships of biological macromolecules, in particular proteins, provide crucial insights for fundamental biochemistry, medical research and early drug discovery. However, production of recombinant proteins, either for structure determination, functional...
6.
Axford D, Judge P, Bada Juarez J, Kwan T, Birch J, Vinals J, et al.
Acta Crystallogr D Struct Biol
. 2022 Jan;
78(Pt 1):52-58.
PMID: 34981761
Room-temperature diffraction methods are highly desirable for dynamic studies of biological macromolecules, since they allow high-resolution structural data to be collected as proteins undergo conformational changes. For crystals grown in...
7.
Moraes I, Quigley A
Biology (Basel)
. 2021 Apr;
10(3).
PMID: 33809831
To understand the biological complexity of life, one needs to investigate how biomolecules behave and interact with each other at a molecular level [...].
8.
Bada Juarez J, Judge P, Adam S, Axford D, Vinals J, Birch J, et al.
Nat Commun
. 2021 Jan;
12(1):629.
PMID: 33504778
Many transmembrane receptors have a desensitized state, in which they are unable to respond to external stimuli. The family of microbial rhodopsin proteins includes one such group of receptors, whose...
9.
Quesnay J, Pollock N, Nagampalli R, Lee S, Balakrishnan V, Dias S, et al.
Biology (Basel)
. 2020 Nov;
9(11).
PMID: 33227948
The molecular identity of the mitochondrial pyruvate carrier (MPC) was presented in 2012, forty years after the active transport of cytosolic pyruvate into the mitochondrial matrix was first demonstrated. An...
10.
Reis R, Moraes I
Biology (Basel)
. 2020 Nov;
9(11).
PMID: 33202740
Membrane proteins play a crucial role in cell physiology by participating in a variety of essential processes such as transport, signal transduction and cell communication. Hence, understanding their structure-function relationship...