James B Lok
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Explore the profile of James B Lok including associated specialties, affiliations and a list of published articles.
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71
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Recent Articles
1.
Lok J, Kliewer S, Mangelsdorf D
Mol Biochem Parasitol
. 2022 Jun;
250:111490.
PMID: 35697206
Mechanisms governing morphogenesis and development of infectious third-stage larvae (L3i) of parasitic nematodes have been likened to those regulating dauer development in Caenorhabditis elegans. Dauer regulatory signal transduction comprises initial...
2.
Wang Z, Cheong M, Tsien J, Deng H, Qin T, Stoltzfus J, et al.
Elife
. 2021 Dec;
10.
PMID: 34874004
A prevalent feature of is a life-long and potentially lethal infection that is due to the nematode parasite's ability to autoinfect and, thereby, self-replicate within its host. Here, we investigated...
3.
Springer L, Patton J, Zhan T, Rabson A, Lin H, Manser T, et al.
PLoS Negl Trop Dis
. 2021 Jul;
15(7):e0009559.
PMID: 34314415
Viral and parasitic coinfections are known to lead to both enhanced disease progression and altered disease states. HTLV-1 and Strongyloides stercoralis are co-endemic throughout much of their worldwide ranges resulting...
4.
Ahmad H, Arifin N, Nolan T, Lok J, Anuar N, Noordin R
Diagnostics (Basel)
. 2021 Jun;
11(6).
PMID: 34071716
Strongyloidiasis, caused mainly by the nematode , is prevalent worldwide and potentially fatal in immunosuppressed patients. We report on a new IgE biomarker to diagnose infection. Sera from two groups...
5.
Gonzalez Akimori D, Dalessandro E, Nolan T, Stieha C, Lok J, Stoltzfus J
Sci Rep
. 2021 Apr;
11(1):8254.
PMID: 33859232
The human and canine parasitic nematode Strongyloides stercoralis utilizes an XX/XO sex determination system, with parasitic females reproducing by mitotic parthenogenesis and free-living males and females reproducing sexually. However, the...
6.
Cheong M, Wang Z, Jaleta T, Li X, Lok J, Kliewer S, et al.
Proc Natl Acad Sci U S A
. 2021 Feb;
118(8).
PMID: 33602820
DAF-12 is nematode-specific nuclear receptor that has been proposed to govern development of the infectious stage of parasitic species, including Here, we identified a parasite-specific coactivator, called DAF-12 interacting protein-1...
7.
McCrea A, Edgerton E, Oliver G, ONeill F, Nolan T, Lok J, et al.
Parasit Vectors
. 2021 Jan;
14(1):30.
PMID: 33413579
Background: Mosquitoes transmit filarial nematodes to both human and animal hosts, with worldwide health and economic consequences. Transmission to a vertebrate host requires that ingested microfilariae develop into infective third-stage...
8.
Ahmad H, Balachandra D, Arifin N, Nolan T, Lok J, Hayat Khan A, et al.
Am J Trop Med Hyg
. 2020 Sep;
103(6):2288-2293.
PMID: 32996454
infection is prevalent worldwide and can cause lifelong infection in immunocompetent individuals, and potentially death in immunosuppressed patients. The diagnosis is hindered by the low sensitivity of microscopic examination, thus...
9.
Edgerton E, McCrea A, Berry C, Kwok J, Thompson L, Watson B, et al.
Proc Natl Acad Sci U S A
. 2020 Feb;
117(7):3711-3717.
PMID: 32015105
Mosquito-borne helminth infections are responsible for a significant worldwide disease burden in both humans and animals. Accordingly, development of novel strategies to reduce disease transmission by targeting these pathogens in...
10.
Jaleta T, Lok J
Curr Trop Med Rep
. 2020 Jan;
6(4):161-178.
PMID: 31929961
Purpose Of Review: This paper constitutes an update of recent studies on the general biology, molecular genetics, and cellular biology of spp. and related parasitic nematodes. Recent Findings: Increasingly, human...