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Holman C Massey Jr

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Citations 329
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Recent Articles
1.
Massey Jr H, Ranjit N, Stoltzfus J, Lok J
Int J Parasitol . 2013 Mar; 43(7):515-20. PMID: 23500073
We hypothesise that developmental arrest in infectious larvae of parasitic nematodes is regulated by signalling pathways homologous to Caenorhabditis elegans DAF (dauer formation) pathways. Alignment of Strongyloides stercoralis (Ss) DAF-2...
2.
Shao H, Li X, Nolan T, Massey Jr H, Pearce E, Lok J
PLoS Pathog . 2012 Aug; 8(8):e1002871. PMID: 22912584
Genetic transformation is a potential tool for analyzing gene function and thereby identifying new drug and vaccine targets in parasitic nematodes, which adversely affect more than one billion people. We...
3.
Stoltzfus J, Massey Jr H, Nolan T, Griffith S, Lok J
PLoS One . 2012 Jun; 7(6):e38587. PMID: 22701676
Infective third-stage larvae (L3i) of the human parasite Strongyloides stercoralis share many morphological, developmental, and behavioral attributes with Caenorhabditis elegans dauer larvae. The 'dauer hypothesis' predicts that the same molecular...
4.
Li X, Shao H, Junio A, Nolan T, Massey Jr H, Pearce E, et al.
Mol Biochem Parasitol . 2011 Jul; 179(2):114-9. PMID: 21723330
Strongyloides and related genera are advantageous subjects for transgenesis in parasitic nematodes, primarily by gonadal microinjection as has been used with Caenorhabditis elegans. Transgenesis has been achieved in Strongyloides stercoralis...
5.
Hu M, Lok J, Ranjit N, Massey Jr H, Sternberg P, Gasser R
Int J Parasitol . 2009 Oct; 40(4):405-15. PMID: 19796644
Despite their phylogenetic diversity, parasitic nematodes share attributes of longevity and developmental arrest (=hypobiosis) with free-living nematodes at key points in their life cycles, particularly in larval stages responsible for...
6.
Castelletto M, Massey Jr H, Lok J
PLoS Pathog . 2009 Apr; 5(4):e1000370. PMID: 19360119
Based on metabolic and morphological similarities between infective third-stage larvae of parasitic nematodes and dauer larvae of Caenorhabditis elegans, it is hypothesized that similar genetic mechanisms control the development of...
7.
Junio A, Li X, Massey Jr H, Nolan T, Lamitina S, Sundaram M, et al.
Exp Parasitol . 2007 Oct; 118(2):253-65. PMID: 17945217
Transgenesis is a valuable methodology for studying gene expression patterns and gene function. It has recently become available for research on some parasitic nematodes, including Strongyloides stercoralis. Previously, we described...
8.
Li X, Massey Jr H, Nolan T, Schad G, Kraus K, Sundaram M, et al.
Int J Parasitol . 2006 Feb; 36(6):671-9. PMID: 16500658
Critical investigations into the cellular and molecular biology of parasitic nematodes have been hindered by a lack of modern molecular genetic techniques for these organisms. One such technique is transgenesis....
9.
Massey Jr H, Bhopale M, Li X, Castelletto M, Lok J
Int J Parasitol . 2006 Jan; 36(3):347-52. PMID: 16442538
The purpose of this study was to determine whether Strongyloides stercoralis FKTF-1, a transcription factor of the FOXO/FKH family and the likely output of insulin/IGF signal transduction in that parasite,...
10.
Massey Jr H, Nishi M, Chaudhary K, Pakpour N, Lok J
Int J Parasitol . 2003 Oct; 33(13):1537-44. PMID: 14572516
A forkhead transcription factor gene, fktf-1, which we propose to be orthologous to the Caenorhabditis elegans dauer-regulatory gene daf-16 has been discovered in the parasitic nematode Strongyloides stercoralis. Genomic and...