Jake F Watson
Overview
Explore the profile of Jake F Watson including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
630
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0
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Recent Articles
1.
Watson J, Vargas-Barroso V, Morse-Mora R, Navas-Olive A, Tavakoli M, Danzl J, et al.
Cell
. 2024 Dec;
188(2):501-514.e18.
PMID: 39667938
Our brain has remarkable computational power, generating sophisticated behaviors, storing memories over an individual's lifetime, and producing higher cognitive functions. However, little of our neuroscience knowledge covers the human brain....
2.
Stockwell I, Watson J, Greger I
Bioessays
. 2024 May;
46(7):e2400006.
PMID: 38693811
Long-term potentiation (LTP) of excitatory synapses is a leading model to explain the concept of information storage in the brain. Multiple mechanisms contribute to LTP, but central amongst them is...
3.
Michalska J, Lyudchik J, Velicky P, Stefanickova H, Watson J, Cenameri A, et al.
Nat Biotechnol
. 2023 Aug;
42(7):1051-1064.
PMID: 37653226
Mapping the complex and dense arrangement of cells and their connectivity in brain tissue demands nanoscale spatial resolution imaging. Super-resolution optical microscopy excels at visualizing specific molecules and individual cells...
4.
Velicky P, Miguel E, Michalska J, Lyudchik J, Wei D, Lin Z, et al.
Nat Methods
. 2023 Jul;
20(8):1256-1265.
PMID: 37429995
Three-dimensional (3D) reconstruction of living brain tissue down to an individual synapse level would create opportunities for decoding the dynamics and structure-function relationships of the brain's complex and dense information...
5.
Zhang D, Lape R, Shaikh S, Kohegyi B, Watson J, Cais O, et al.
Nat Commun
. 2023 Mar;
14(1):1659.
PMID: 36966141
AMPA glutamate receptors (AMPARs) mediate excitatory neurotransmission throughout the brain. Their signalling is uniquely diversified by brain region-specific auxiliary subunits, providing an opportunity for the development of selective therapeutics. AMPARs...
6.
Arroyo-Urea S, Watson J, Garcia-Nafria J
Methods Mol Biol
. 2023 Feb;
2633:33-44.
PMID: 36853454
Here we describe the in vivo DNA assembly approach, where molecular cloning procedures are performed using an E. coli recA-independent recombination pathway, which assembles linear fragments of DNA with short...
7.
Herguedas B, Kohegyi B, Dohrke J, Watson J, Zhang D, Ho H, et al.
Nat Commun
. 2022 Feb;
13(1):734.
PMID: 35136046
AMPA-type glutamate receptors (AMPARs) mediate rapid signal transmission at excitatory synapses in the brain. Glutamate binding to the receptor's ligand-binding domains (LBDs) leads to ion channel activation and desensitization. Gating...
8.
Watson J, Pinggera A, Ho H, Greger I
Nat Commun
. 2021 Aug;
12(1):5083.
PMID: 34426577
AMPA receptor (AMPAR) abundance and positioning at excitatory synapses regulates the strength of transmission. Changes in AMPAR localisation can enact synaptic plasticity, allowing long-term information storage, and is therefore tightly...
9.
Zhang D, Watson J, Matthews P, Cais O, Greger I
Nature
. 2021 Jun;
594(7863):454-458.
PMID: 34079129
AMPA receptors (AMPARs) mediate the majority of excitatory transmission in the brain and enable the synaptic plasticity that underlies learning. A diverse array of AMPAR signalling complexes are established by...
10.
Dohrke J, Watson J, Birchall K, Greger I
J Biol Chem
. 2020 Aug;
295(43):14565-14577.
PMID: 32747446
α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid(AMPA)-type glutamate receptors (AMPARs) are the predominant excitatory neurotransmitter receptors in the brain, where they mediate synaptic transmission and plasticity. Excessive AMPAR activation leads to diseases such as epilepsy....