Jagath R Junutula
Overview
Explore the profile of Jagath R Junutula including associated specialties, affiliations and a list of published articles.
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46
Citations
2776
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Recent Articles
11.
Trefely S, Khoo P, Krycer J, Chaudhuri R, Fazakerley D, Parker B, et al.
J Biol Chem
. 2015 Sep;
290(43):25834-46.
PMID: 26342081
The insulin/insulin-like growth factor (IGF)-1 signaling pathway (ISP) plays a fundamental role in long term health in a range of organisms. Protein kinases including Akt and ERK are intimately involved...
12.
Hocking S, Stewart R, Brandon A, Suryana E, Stuart E, Baldwin E, et al.
Diabetologia
. 2015 Apr;
58(7):1587-600.
PMID: 25899451
Aims/hypothesis: Adipose tissue (AT) distribution is a major determinant of mortality and morbidity in obesity. In mice, intra-abdominal transplantation of subcutaneous AT (SAT) protects against glucose intolerance and insulin resistance...
13.
Sukumaran S, Gadkar K, Zhang C, Bhakta S, Liu L, Xu K, et al.
Pharm Res
. 2014 Dec;
32(6):1884-93.
PMID: 25446772
Purpose: THIOMAB™ drug conjugates (TDCs) with engineered cysteine residues allow site-specific drug conjugation and defined Drug-to-Antibody Ratios (DAR). In order to help elucidate the impact of drug-loading, conjugation site, and...
14.
Pillow T, Tien J, Parsons-Reponte K, Bhakta S, Li H, Staben L, et al.
J Med Chem
. 2014 Sep;
57(19):7890-9.
PMID: 25191794
Antibody-drug conjugates (ADCs) have a significant impact toward the treatment of cancer, as evidenced by the clinical activity of the recently approved ADCs, brentuximab vedotin for Hodgkin lymphoma and ado-trastuzumab...
15.
Bos A, Duque J, Bhakta S, Farahi F, Chirdon L, Junutula J, et al.
J Biotechnol
. 2014 Apr;
180:10-6.
PMID: 24704608
Transient transfection of mammalian cells provides a rapid method of producing protein for research purposes. Combining the transient transfection protein expression system with new automation technologies developed for the biotechnology...
16.
Panowski S, Bhakta S, Raab H, Polakis P, Junutula J
MAbs
. 2014 Jan;
6(1):34-45.
PMID: 24423619
Antibody therapeutics have revolutionized the treatment of cancer over the past two decades. Antibodies that specifically bind tumor surface antigens can be effective therapeutics; however, many unmodified antibodies lack therapeutic...
17.
Boswell C, Marik J, Elowson M, Reyes N, Ulufatu S, Bumbaca D, et al.
J Med Chem
. 2013 Oct;
56(23):9418-26.
PMID: 24131491
A known limitation of iodine radionuclides for labeling and biological tracking of receptor targeted proteins is the tendency of iodotyrosine to rapidly diffuse from cells following endocytosis and lysosomal degradation....
18.
Hazen M, Bhakta S, Vij R, Randle S, Kallop D, Chiang V, et al.
MAbs
. 2013 Oct;
6(1):95-107.
PMID: 24121517
Multi-transmembrane proteins are especially difficult targets for antibody generation largely due to the challenge of producing a protein that maintains its native conformation in the absence of a stabilizing membrane....
19.
Bhakta S, Raab H, Junutula J
Methods Mol Biol
. 2013 Aug;
1045:189-203.
PMID: 23913148
Antibody conjugates are used in many therapeutic and research applications and are generated by chemically linking a cysteine or lysine residue to potent chemotherapeutic drugs or other functional groups through...
20.
Jacob A, Jing J, Lee J, Schedin P, Gilbert S, Peden A, et al.
J Cell Sci
. 2013 Aug;
126(Pt 20):4647-58.
PMID: 23902685
Invadopodia-dependent degradation of the basement membrane plays a major role during metastasis of breast cancer cells. Basement membrane degradation is mediated by targeted secretion of various matrix metalloproteinases (MMPs). Specifically,...