Richard H Scheller
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Explore the profile of Richard H Scheller including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
4441
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Recent Articles
1.
Bhakta S, Crocker L, Chen Y, Hazen M, Schutten M, Li D, et al.
Mol Cancer Ther
. 2019 Nov;
18(11):2182.
PMID: 31676543
No abstract available.
2.
Bhakta S, Crocker L, Chen Y, Hazen M, Schutten M, Li D, et al.
Mol Cancer Ther
. 2017 Dec;
17(3):638-649.
PMID: 29282299
Luminal A (hormone receptor-positive) breast cancer constitutes 70% of total breast cancer patients. In an attempt to develop a targeted therapeutic for this cancer indication, we have identified and characterized...
3.
Pillow T, Tien J, Parsons-Reponte K, Bhakta S, Li H, Staben L, et al.
J Med Chem
. 2014 Sep;
57(19):7890-9.
PMID: 25191794
Antibody-drug conjugates (ADCs) have a significant impact toward the treatment of cancer, as evidenced by the clinical activity of the recently approved ADCs, brentuximab vedotin for Hodgkin lymphoma and ado-trastuzumab...
4.
Hazen M, Bhakta S, Vij R, Randle S, Kallop D, Chiang V, et al.
MAbs
. 2013 Oct;
6(1):95-107.
PMID: 24121517
Multi-transmembrane proteins are especially difficult targets for antibody generation largely due to the challenge of producing a protein that maintains its native conformation in the absence of a stabilizing membrane....
5.
6.
Kuijl C, Pilli M, Alahari S, Janssen H, Khoo P, Ervin K, et al.
EMBO J
. 2013 Feb;
32(5):713-27.
PMID: 23386062
The intracellular pathogenic bacterium Salmonella enterica serovar typhimurium (Salmonella) relies on acidification of the Salmonella-containing vacuole (SCV) for survival inside host cells. The transport and fusion of membrane-bound compartments in...
7.
Shen B, Xu K, Liu L, Raab H, Bhakta S, Kenrick M, et al.
Nat Biotechnol
. 2012 Jan;
30(2):184-9.
PMID: 22267010
The reactive thiol in cysteine is used for coupling maleimide linkers in the generation of antibody conjugates. To assess the impact of the conjugation site, we engineered cysteines into a...
8.
Westlake C, Baye L, Nachury M, Wright K, Ervin K, Phu L, et al.
Proc Natl Acad Sci U S A
. 2011 Jan;
108(7):2759-64.
PMID: 21273506
Sensory and signaling pathways are exquisitely organized in primary cilia. Bardet-Biedl syndrome (BBS) patients have compromised cilia and signaling. BBS proteins form the BBSome, which binds Rabin8, a guanine nucleotide...
9.
Junutula J, Flagella K, Graham R, Parsons K, Ha E, Raab H, et al.
Clin Cancer Res
. 2010 Sep;
16(19):4769-78.
PMID: 20805300
Purpose: Antibody drug conjugates (ADCs) combine the ideal properties of both antibodies and cytotoxic drugs by targeting potent drugs to the antigen-expressing tumor cells, thereby enhancing their antitumor activity. Successful...
10.