Jae-Seon Lee
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Explore the profile of Jae-Seon Lee including associated specialties, affiliations and a list of published articles.
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133
Citations
2534
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Recent Articles
11.
Kang D, Baek Y, Lee J
Cells
. 2022 Dec;
11(24).
PMID: 36552825
Cellular senescence, a hallmark of aging, is defined as irreversible cell cycle arrest in response to various stimuli. It plays both beneficial and detrimental roles in cellular homeostasis and diseases....
12.
Bahn M, Yu D, Lee M, Jo S, Lee J, Kim H, et al.
Nat Commun
. 2022 Oct;
13(1):6219.
PMID: 36266314
Prominin-1, a lipid raft protein, is required for maintaining cancer stem cell properties in hepatocarcinoma cell lines, but its physiological roles in the liver have not been well studied. Here,...
13.
Hwang H, Kim N, Herman A, Gorospe M, Lee J
Int J Mol Sci
. 2022 Sep;
23(17).
PMID: 36077539
Aging causes a progressive decline in the structure and function of organs. With advancing age, an accumulation of senescent endothelial cells (ECs) contributes to the risk of developing vascular dysfunction...
14.
Lee H, Yu D, Bahn M, Kwon Y, Um M, Yoon S, et al.
Exp Mol Med
. 2022 Aug;
54(8):1277-1289.
PMID: 36038590
Prominin-1 (PROM1), also known as CD133, is expressed in hepatic progenitor cells (HPCs) and cholangiocytes of the fibrotic liver. In this study, we show that PROM1 is upregulated in the...
15.
Oh E, Kim H, Choi M, Lee J, Kim S, Kwak J, et al.
Cancers (Basel)
. 2021 Jul;
13(14).
PMID: 34298763
Three-dimensional (3D) cancer cell culture systems have been developed to aid the study of molecular mechanisms in cancer development, identify therapeutic targets, and test drug candidates. In this study, we...
16.
Han H, Sung J, Kim S, Yun U, Kim H, Jang E, et al.
Cancer Lett
. 2021 Mar;
508:59-72.
PMID: 33771684
The loss of cell-matrix interactions induces apoptosis, known as anoikis. For successful distant metastasis, circulating tumor cells (CTCs) that have lost matrix attachment need to acquire anoikis resistance in order...
17.
Lee J, Lee H, Woo S, Jang H, Jeon Y, Kim H, et al.
Theranostics
. 2021 Feb;
11(7):3472-3488.
PMID: 33537098
The activity of aldehyde dehydrogenase 7A1 (ALDH7A1), an enzyme that catalyzes the lipid peroxidation of fatty aldehydes was found to be upregulated in pancreatic ductal adenocarcinoma (PDAC). knockdown significantly reduced...
18.
Lee J, Choi J, Lee S, Kang J, Ha J, Kim H, et al.
Pharmaceutics
. 2020 Nov;
12(11).
PMID: 33238375
Recent findings indicate that (a) mitochondria in proliferating cancer cells are functional, (b) cancer cells use more oxygen than normal cells for oxidative phosphorylation, and (c) cancer cells critically rely...
19.
Lim G, Sung J, Yu S, Kim Y, Shim J, Kim H, et al.
Int J Mol Sci
. 2020 Nov;
21(22).
PMID: 33182770
Metastasis is the main cause of cancer-related deaths. Anoikis is a type of apoptosis caused by cell detachment, and cancer cells become anoikis resistant such that they survive during circulation...
20.
Lee H, Yu D, Park J, Lee H, Kim J, Kim H, et al.
EMBO Rep
. 2020 Oct;
21(11):e49416.
PMID: 33030802
Prominin-1 (Prom1) is a major cell surface marker of cancer stem cells, but its physiological functions in the liver have not been elucidated. We analyzed the levels of mRNA transcripts...