Seon-Hyeong Lee
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Explore the profile of Seon-Hyeong Lee including associated specialties, affiliations and a list of published articles.
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31
Citations
566
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Recent Articles
1.
Choi E, Oh H, Lee S, Zhang C, Li M, Kim S, et al.
Autophagy
. 2024 Jul;
20(11):2490-2510.
PMID: 38953310
Co-occurring mutations in KEAP1 in STK11/LKB1-mutant NSCLC activate NFE2L2/NRF2 to compensate for the loss of STK11-AMPK activity during metabolic adaptation. Characterizing the regulatory crosstalk between the STK11-AMPK and KEAP1-NFE2L2 pathways...
2.
Lee E, Kim N, Kang J, Abdildinova A, Lee S, Lee M, et al.
Pharmaceuticals (Basel)
. 2022 May;
15(5).
PMID: 35631329
Cancer cells are characterized by an abnormal cell cycle. Therefore, the cell cycle has been a potential target for cancer therapeutic agents. We developed a new lead compound, () with...
3.
Lee S, Jeon Y, Kang J, Jang H, Hong K, Hong D, et al.
Cancers (Basel)
. 2021 Jun;
13(9).
PMID: 34066916
In the Cancers paper, we observed the increase ALDH1L1 protein expression following oncogenesis, as well as a therapeutic effect, by deleting the gene in mice, a model of spontaneous non-small...
4.
Lee J, Choi J, Lee S, Kang J, Ha J, Kim H, et al.
Pharmaceutics
. 2020 Nov;
12(11).
PMID: 33238375
Recent findings indicate that (a) mitochondria in proliferating cancer cells are functional, (b) cancer cells use more oxygen than normal cells for oxidative phosphorylation, and (c) cancer cells critically rely...
5.
Kim D, Song B, Han S, Jang H, Bae S, Kim H, et al.
Cancers (Basel)
. 2020 Sep;
12(9).
PMID: 32932964
Octamer-binding transcription factor 4 (Oct4) plays an important role in maintaining pluripotency in embryonic stem cells and is closely related to the malignancies of various cancers. Although posttranslational modifications of...
6.
Lee J, Lee H, Jang H, Woo S, Park J, Lee S, et al.
Cells
. 2020 Sep;
9(9).
PMID: 32883024
The greatest challenge in cancer therapy is posed by drug-resistant recurrence following treatment. Anticancer chemotherapy is largely focused on targeting the rapid proliferation and biosynthesis of cancer cells. This strategy...
7.
Lee J, Oh S, Choi H, Kang J, Lee S, Ha J, et al.
Cancers (Basel)
. 2020 Sep;
12(9).
PMID: 32882923
Glycolysis is known as the main pathway for ATP production in cancer cells. However, in cancer cells, glucose deprivation for 24 h does not reduce ATP levels, whereas it does...
8.
Lee S, Kang J, Ha J, Lee J, Oh S, Choi H, et al.
Int J Mol Sci
. 2020 Jul;
21(14).
PMID: 32708896
Angiogenesis and the expression of vascular endothelial growth factor (VEGF) are increased in renal cell carcinoma (RCC). Transglutaminase 2 (TGase 2), which promotes angiogenesis in endothelial cells during wound healing,...
9.
Kang J, Lee S, Lee J, Oh S, Ha J, Choi H, et al.
Cells
. 2020 Jun;
9(6).
PMID: 32560270
More than 50% of human cancers harbor mutations and increased expression of , which contribute to cancer progression and drug resistance. Renal cell carcinoma (RCC) has an unusually high incidence...
10.
Yang J, Kim N, Yun J, Cho E, Cha Y, Cho S, et al.
Life Sci Alliance
. 2020 Jun;
3(7).
PMID: 32487689
Despite the importance of mitochondrial fatty acid oxidation (FAO) in cancer metabolism, the biological mechanisms responsible for the FAO in cancer and therapeutic intervention based on catabolic metabolism are not...