Jacques Genest
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Explore the profile of Jacques Genest including associated specialties, affiliations and a list of published articles.
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207
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12184
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Recent Articles
1.
Choi H, Ruel I, Choi S, Iatan I, Choi S, Lee J, et al.
Int J Mol Sci
. 2025 Feb;
26(4).
PMID: 40003949
High-density lipoprotein (HDL) particles form during cellular cholesterol removal, positioning HDL biogenesis as a potential strategy to combat atherosclerosis. We identified desmocollin 1 (DSC1) as a negative regulator of HDL...
2.
Paquette M, Trinder M, Ruel I, Guay S, Hegele R, Genest J, et al.
J Clin Lipidol
. 2025 Feb;
PMID: 40000284
Background: Patients with familial hypercholesterolemia (FH) are at increased risk of atherosclerotic cardiovascular disease (ASCVD). However, this risk is heterogeneous, and the contribution of several clinical risk factors has been...
3.
Paquette M, Ruel I, Guay S, Al-Baldawi Z, Brisson D, Gaudet D, et al.
J Clin Lipidol
. 2024 Dec;
19(1):105-113.
PMID: 39638644
Background: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disease of low-density lipoprotein cholesterol (LDL-C) metabolism. Despite the devastating effect of this disease on atherosclerotic cardiovascular health, the disease phenotype...
4.
Mancini G, Pearson G, Barry A, Couture P, Dayan N, Francis G, et al.
CJC Open
. 2024 Nov;
6(10):1189-1198.
PMID: 39525338
Background: In Canada, 2 guidelines provide guidance for the management of dyslipidemia. The Patients, Experience, Evidence, Research simplified lipid guidelines, intended for primary care practitioners, and the Canadian Cardiovascular Society...
5.
Iatan I, Akioyamen L, Ruel I, Guerin A, Hales L, Coutinho T, et al.
Eur Heart J
. 2024 Jul;
45(35):3231-3250.
PMID: 38976372
Background And Aims: Familial hypercholesterolaemia (FH) is a highly prevalent monogenic disorder characterized by elevated LDL cholesterol (LDL-C) levels and premature atherosclerotic cardiovascular disease. Sex disparities in diagnosis, lipid-lowering therapy,...
6.
McCallum R, Kramer A, Marchand M, Akioyamen L, Genest J, Brunham L
JACC Adv
. 2024 Jun;
2(3):100315.
PMID: 38939583
Background: Hypercholesterolemia is a common condition characterized by elevated levels of low-density lipoprotein cholesterol (LDL-C) and increased risk of atherosclerotic cardiovascular disease (ASCVD). Indigenous populations experience disproportionate rates of ASCVD,...
7.
Brown L, Ruel I, Baass A, Bergeron J, Brunham L, Cermakova L, et al.
JACC Adv
. 2024 Jun;
2(3):100309.
PMID: 38939573
Background: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disease characterized by very high levels of low-density lipoprotein cholesterol (LDL-C). Untreated patients present with extensive xanthomas and premature atherosclerosis. Lipid-lowering...
8.
Trinder M, Cermakova L, Ruel I, Baass A, Paquette M, Wang J, et al.
Arterioscler Thromb Vasc Biol
. 2024 May;
44(7):1683-1693.
PMID: 38779854
Background: Heterozygous familial hypercholesterolemia (FH) is among the most common genetic conditions worldwide that affects ≈ 1 in 300 individuals. FH is characterized by increased levels of low-density lipoprotein cholesterol...
9.
Khan K, Yu B, Tardif J, Rheaume E, Al-Kindi H, Filimon S, et al.
Front Cardiovasc Med
. 2024 Apr;
11:1360380.
PMID: 38586172
Introduction: The progression of coronary atherosclerosis is an active and regulated process. The Wnt signaling pathway is thought to play an active role in the pathogenesis of several cardiovascular diseases;...
10.
Akl E, Sahami N, Labos C, Genest J, Zgheib A, Piazza N, et al.
J Interv Cardiol
. 2024 Mar;
2024:8646351.
PMID: 38505729
Background: Colchicine has shown potential cardioprotective effects owing to its broad anti-inflammatory properties. We performed a meta-analysis to assess its safety and efficacy in secondary prevention in patients with established...