Isabelle Ruel
Overview
Explore the profile of Isabelle Ruel including associated specialties, affiliations and a list of published articles.
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52
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650
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Recent Articles
1.
Choi H, Ruel I, Choi S, Iatan I, Choi S, Lee J, et al.
Int J Mol Sci
. 2025 Feb;
26(4).
PMID: 40003949
High-density lipoprotein (HDL) particles form during cellular cholesterol removal, positioning HDL biogenesis as a potential strategy to combat atherosclerosis. We identified desmocollin 1 (DSC1) as a negative regulator of HDL...
2.
Paquette M, Trinder M, Ruel I, Guay S, Hegele R, Genest J, et al.
J Clin Lipidol
. 2025 Feb;
PMID: 40000284
Background: Patients with familial hypercholesterolemia (FH) are at increased risk of atherosclerotic cardiovascular disease (ASCVD). However, this risk is heterogeneous, and the contribution of several clinical risk factors has been...
3.
Paquette M, Ruel I, Guay S, Al-Baldawi Z, Brisson D, Gaudet D, et al.
J Clin Lipidol
. 2024 Dec;
19(1):105-113.
PMID: 39638644
Background: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disease of low-density lipoprotein cholesterol (LDL-C) metabolism. Despite the devastating effect of this disease on atherosclerotic cardiovascular health, the disease phenotype...
4.
Iatan I, Akioyamen L, Ruel I, Guerin A, Hales L, Coutinho T, et al.
Eur Heart J
. 2024 Jul;
45(35):3231-3250.
PMID: 38976372
Background And Aims: Familial hypercholesterolaemia (FH) is a highly prevalent monogenic disorder characterized by elevated LDL cholesterol (LDL-C) levels and premature atherosclerotic cardiovascular disease. Sex disparities in diagnosis, lipid-lowering therapy,...
5.
Brown L, Ruel I, Baass A, Bergeron J, Brunham L, Cermakova L, et al.
JACC Adv
. 2024 Jun;
2(3):100309.
PMID: 38939573
Background: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disease characterized by very high levels of low-density lipoprotein cholesterol (LDL-C). Untreated patients present with extensive xanthomas and premature atherosclerosis. Lipid-lowering...
6.
Trinder M, Cermakova L, Ruel I, Baass A, Paquette M, Wang J, et al.
Arterioscler Thromb Vasc Biol
. 2024 May;
44(7):1683-1693.
PMID: 38779854
Background: Heterozygous familial hypercholesterolemia (FH) is among the most common genetic conditions worldwide that affects ≈ 1 in 300 individuals. FH is characterized by increased levels of low-density lipoprotein cholesterol...
7.
Al-Baldawi Z, Brown L, Ruel I, Baass A, Bergeron J, Cermakova L, et al.
J Clin Lipidol
. 2024 Jan;
18(2):e189-e196.
PMID: 38281851
Background: Homozygous familial hypercholesterolemia (HoFH) is a rare, autosomal semi-dominant lipid metabolism disorder characterized by extremely high low-density lipoprotein cholesterol (LDL-C) levels and premature cardiovascular disease. The objective of this...
8.
Alshibani B, Iatan I, Guerin A, Ruel I, Cermakova L, Ramanakumar A, et al.
J Clin Lipidol
. 2023 Nov;
18(1):e97-e104.
PMID: 37926591
Background: Familial hypercholesterolemia (FH), a common genetic condition, is characterized by elevated low-density lipoprotein cholesterol (LDL-C) and premature atherosclerotic cardiovascular disease (ASCVD). Recent data indicate an undertreatment of females with...
9.
Guerin A, Iatan I, Ruel I, Ngufor L, Genest J
CMAJ Open
. 2023 Aug;
11(4):E754-E764.
PMID: 37607748
Background: Familial hypercholesterolemia (FH) is associated with premature atherosclerotic cardiovascular disease caused by elevated low-density lipoprotein cholesterol (LDL-C) levels. We determined the impact of a full next-generation sequencing (NGS) genetic...
10.
Choi H, Iatan I, Ruel I, Brown L, Hales L, Choi S, et al.
Arterioscler Thromb Vasc Biol
. 2023 Mar;
43(5):609-617.
PMID: 36861478
The recent identification of the cell-surface protein DSC1 (desmocollin 1) as a negative regulator of HDL (high-density lipoprotein) biogenesis has attracted us to revisit the old HDL biogenesis hypothesis: HDL...