Jacques Genest
Overview
Explore the profile of Jacques Genest including associated specialties, affiliations and a list of published articles.
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Articles
207
Citations
12184
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Recent Articles
11.
Al-Baldawi Z, Brown L, Ruel I, Baass A, Bergeron J, Cermakova L, et al.
J Clin Lipidol
. 2024 Jan;
18(2):e189-e196.
PMID: 38281851
Background: Homozygous familial hypercholesterolemia (HoFH) is a rare, autosomal semi-dominant lipid metabolism disorder characterized by extremely high low-density lipoprotein cholesterol (LDL-C) levels and premature cardiovascular disease. The objective of this...
12.
Paquette M, Cariou B, Bernard S, Hegele R, Gallo A, Genest J, et al.
Arterioscler Thromb Vasc Biol
. 2023 Nov;
44(2):505-512.
PMID: 38031840
Background: Familial hypercholesterolemia (FH) is a genetic condition causing premature atherosclerotic cardiovascular disease (ASCVD). It is well established that patients with FH should be treated with statin therapy. However, there...
13.
Alshibani B, Iatan I, Guerin A, Ruel I, Cermakova L, Ramanakumar A, et al.
J Clin Lipidol
. 2023 Nov;
18(1):e97-e104.
PMID: 37926591
Background: Familial hypercholesterolemia (FH), a common genetic condition, is characterized by elevated low-density lipoprotein cholesterol (LDL-C) and premature atherosclerotic cardiovascular disease (ASCVD). Recent data indicate an undertreatment of females with...
14.
Guerin A, Iatan I, Ruel I, Ngufor L, Genest J
CMAJ Open
. 2023 Aug;
11(4):E754-E764.
PMID: 37607748
Background: Familial hypercholesterolemia (FH) is associated with premature atherosclerotic cardiovascular disease caused by elevated low-density lipoprotein cholesterol (LDL-C) levels. We determined the impact of a full next-generation sequencing (NGS) genetic...
15.
Paquette M, Bernard S, Cariou B, Hegele R, Genest J, Trinder M, et al.
J Clin Lipidol
. 2023 Apr;
17(3):376-383.
PMID: 37003850
Background: The association between familial hypercholesterolemia (FH) and premature atherosclerotic cardiovascular disease (ASCVD) is well established. Several risk factors other than the cumulative low-density lipoprotein cholesterol (LDL-C) have been shown...
16.
17.
Choi H, Iatan I, Ruel I, Brown L, Hales L, Choi S, et al.
Arterioscler Thromb Vasc Biol
. 2023 Mar;
43(5):609-617.
PMID: 36861478
The recent identification of the cell-surface protein DSC1 (desmocollin 1) as a negative regulator of HDL (high-density lipoprotein) biogenesis has attracted us to revisit the old HDL biogenesis hypothesis: HDL...
18.
Choi H, Choi S, Iatan I, Ruel I, Genest J
Biomedicines
. 2023 Feb;
11(2).
PMID: 36831097
ATP-binding cassette transporter A1 (ABCA1) has been identified as the molecular defect in Tangier disease. It is biochemically characterized by absence of high-density lipoprotein cholesterol (HDL-C) in the circulation, resulting...
19.
Parent M, Lachapelle K, Issa-Chergui B, Alcindor T, Genest J, Mousavi N
Eur Heart J Case Rep
. 2022 Nov;
6(11):ytac412.
PMID: 36381172
Background: Malignant tumours of the aortic valve apparatus are extremely rare and difficult to diagnose. Their proximity to the coronary ostium may cause an acute coronary syndrome (ACS) either by...
20.
Akioyamen L, Chu A, Genest J, Lee D, Abdel-Qadir H, Jackevicius C, et al.
CJC Open
. 2022 Sep;
4(9):739-747.
PMID: 36148251
Background: A simplified Canadian definition was recently developed to enable identification of individuals with familial hypercholesterolemia (FH) and severe hypercholesterolemia in the general population. Our objective was to use a...